March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Disruption Of The Photoreceptor Inner Segment/outer Segment Junction And External Limiting Membrane On Spectral-domain Optical Coherence Tomography Are Predictors Of Visual Outcomes After Primary Epiretinal Membrane Surgery
Kevin Tan; Jay Chhablani; Renato Lisboa; William R. Freeman
Author Affiliations & Notes
  • Kevin Tan
    Jacobs Retina Center, Shiley Eye Center, Dept of Ophthalmology,
    University of California, San Diego, La Jolla, California
  • Jay Chhablani
    Jacobs Retina Center, Shiley Eye Center, Dept of Ophthalmology,
    University of California, San Diego, La Jolla, California
  • Renato Lisboa
    Hamilton Glaucoma Center, Dept of Ophthalmology,
    University of California, San Diego, La Jolla, California
  • William R. Freeman
    Jacobs Retina Center, Shiley Eye Center, Dept of Ophthalmology,
    University of California, San Diego, La Jolla, California
  • Footnotes
    Commercial Relationships  Kevin Tan, None; Jay Chhablani, None; Renato Lisboa, None; William R. Freeman, None
  • Footnotes
    Support  NIH grants R01EY007366 and R01EY018589 (WRF), RPB incorporated and unrestricted funds from Jacobs Retina Center
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2609. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Disruption Of The Photoreceptor Inner Segment/outer Segment Junction And External Limiting Membrane On Spectral-domain Optical Coherence Tomography Are Predictors Of Visual Outcomes After Primary Epiretinal Membrane Surgery
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Kevin Tan, Jay Chhablani, Renato Lisboa, William R. Freeman; Disruption Of The Photoreceptor Inner Segment/outer Segment Junction And External Limiting Membrane On Spectral-domain Optical Coherence Tomography Are Predictors Of Visual Outcomes After Primary Epiretinal Membrane Surgery. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2609.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : The purpose of this study was to evaluate the predictive value of spectral domain-optical coherence tomography (SD-OCT)-determined integrity of the photoreceptor inner segment/outer segment (IS/OS) junction and the external limiting membrane (ELM) on visual acuity in patients undergoing surgery for removal of epiretinal membranes (ERMs).

Methods: : This is a retrospective, consecutive surgical case series of 32 eyes from 31 patients with primary ERMs who underwent spectral domain-optical coherence tomography scans prior to and following ERM surgery. Multivariate regression analysis was used to calculate the relative contribution of several variables, including extent of photoreceptor IS/OS disruption, extent of external limiting membrane (ELM) disruption, and central macular thickness (CMT) to postoperative best corrected visual acuity (BCVA) and change in BCVA.

Results: : The strongest individual predictors of postoperative BCVA among patients who underwent ERM surgery were pre-operative percentage damage of the ELM (r2 = 0.22, P = 0.0075) and pre-operative percentage damage of the IS/OS junction (r2 = 0.24, P = 0.0045) measured on SD-OCT. Interestingly, improvement in visual acuity was correlated with a decrease in CMT (r2 = 0.23, P = 0.021). The most efficient model predicting postoperative BCVA was one which included pre-operative percentage damage of the IS/OS junction, pre-operative percentage damage of the ELM, and the change in CMT (r2 = 0.41, P = 0.001). Additional measured variables did not significantly contribute to visual acuity prediction.

Conclusions: : We demonstrate for the first time that disruption of the photoreceptor IS/OS junction and ELM measured on SD-OCT are statistically significant predictors of poor visual acuity outcomes among patients with ERM who undergo surgery, but is most useful when in combination with postoperative CMT. Quantitative improvement in BCVA after ERM surgery is correlated with a decrease in CMT.

Keywords: macula/fovea • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
© 2012, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept