April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Clinical And Histological Changes In Corneas After Intrastromal Ring Segment Implantation With Or Without Crosslinking
Author Affiliations & Notes
  • Lucia Ibares-Frias
    Histology and molecular biology, University of Valladolid, Valladolid, Spain
  • Patricia Gallego
    Histology and molecular biology, University of Valladolid, Valladolid, Spain
  • Roberto Cantalapiedra
    Histology and molecular biology, University of Valladolid, Valladolid, Spain
  • Pablo Pérez-Merino
    Instituto de Óptica, CSIC, Madrid, Spain
  • Jesús Merayo-Lloves
    Fundación de Investigación Oftalmológica, Oviedo,Spain, Spain
  • Maria Carmen Martinez-García
    Histology and molecular biology, University of Valladolid, Valladolid, Spain
  • Footnotes
    Commercial Relationships  Lucia Ibares-Frias, None; Patricia Gallego, None; Roberto Cantalapiedra, None; Pablo Pérez-Merino, None; Jesús Merayo-Lloves, None; Maria Carmen Martinez-García, None
  • Footnotes
    Support  Spanish Ministry of Science and Innovation (PROFIT CIT-300100-2007-50).
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2541. doi:
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      Lucia Ibares-Frias, Patricia Gallego, Roberto Cantalapiedra, Pablo Pérez-Merino, Jesús Merayo-Lloves, Maria Carmen Martinez-García; Clinical And Histological Changes In Corneas After Intrastromal Ring Segment Implantation With Or Without Crosslinking. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2541.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the stromal wound healing of intrastromal ring segment (ICRS) implantation with and without previous corneal crosslinking in an experimental animal model (hen).

Methods: : We performed surgery for this study in 10 hens (20 eyes) randomly divided into two groups. In the first group, we implanted one intrastromal ring segment by manual Technique (Ferrara Technique) in each eye and then they were followed clinically for 4 months , when we euthanized the animal for histopathological analysis. In the second group, we crosslinked hens’ corneas after epithelial debridement and four months later, implanted the intrastromal ring segment in each eye. They were also followed clinically for 4 months.

Results: : The implantation of the segments in second group was more difficult due to a greater resistance of the cornea. The clinical evolution showed less reaction around the channel. The histopathological analysis showed fewer cells in the stromal scar.

Conclusions: : Corneal crosslinking combined with implantation of ICRS leads to a lower clinical and histopathological wound healing response than implantation alone.

Keywords: refractive surgery: other technologies • keratoconus • wound healing 
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