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Lucia Ibares-Frias, Patricia Gallego, Roberto Cantalapiedra, Pablo Pérez-Merino, Jesús Merayo-Lloves, Maria Carmen Martinez-García; Clinical And Histological Changes In Corneas After Intrastromal Ring Segment Implantation With Or Without Crosslinking. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2541.
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To compare the stromal wound healing of intrastromal ring segment (ICRS) implantation with and without previous corneal crosslinking in an experimental animal model (hen).
We performed surgery for this study in 10 hens (20 eyes) randomly divided into two groups. In the first group, we implanted one intrastromal ring segment by manual Technique (Ferrara Technique) in each eye and then they were followed clinically for 4 months , when we euthanized the animal for histopathological analysis. In the second group, we crosslinked hens’ corneas after epithelial debridement and four months later, implanted the intrastromal ring segment in each eye. They were also followed clinically for 4 months.
The implantation of the segments in second group was more difficult due to a greater resistance of the cornea. The clinical evolution showed less reaction around the channel. The histopathological analysis showed fewer cells in the stromal scar.
Corneal crosslinking combined with implantation of ICRS leads to a lower clinical and histopathological wound healing response than implantation alone.
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