April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Corneal Keratocyte Population after Laser Subepithelial Keratectomy (LASEK) with mitomycin C (MMC). 3 months vs 15 months Comparison
Author Affiliations & Notes
  • Jose Luis Hernandez-Verdejo
    Optometry, Universidad Complutense de Madrid, Madrid, Spain
    VISSUM Corporation, Madrid, Spain
  • Pilar Canadas
    Optometry, Universidad Europea de Madrid, Madrid, Spain
  • Pilar Drake
    VISSUM Corporation, Madrid, Spain
  • Laura De Benito
    Ophthalmology, Vissum Corporation, Madrid, Spain
  • Miguel Teus
    VISSUM Corporation, Madrid, Spain
    Ophthalmology, Universidad de Alcalá, Madrid, Spain
  • Footnotes
    Commercial Relationships  Jose Luis Hernandez-Verdejo, None; Pilar Canadas, None; Pilar Drake, None; Laura De Benito, None; Miguel Teus, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2542. doi:
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      Jose Luis Hernandez-Verdejo, Pilar Canadas, Pilar Drake, Laura De Benito, Miguel Teus; Corneal Keratocyte Population after Laser Subepithelial Keratectomy (LASEK) with mitomycin C (MMC). 3 months vs 15 months Comparison. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2542.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study corneal keratocyte population after LASEK with mitomycin C (MMC) 15 months vs 3 months after surgery.

Methods: : Sixty eyes were included in this study, all of them treated with LASEK with intraoperative 0.02% MMC, divided into 2 groups. 32 eyes had LASEK performed 3 months before, versus 28 in the 15 months post-op group. Keratocyte density was examined by using confocal microscopy in the anterior, mid and posterior stroma in both groups, and the mean density was compared with a control group of healthy eyes.

Results: : Keratocyte density in the anterior stroma was 16993,75+ 8001,7 cells/mm3 and 18529,1 + 2917,7 cells/mm3(p=0,3) in the 3 months and in the 15 months groups respectively, in the mid stroma it was 30783,3+ 9300 cells/mm3 in the 3 months and 20754,7 + 3615,3 cells/mm3 in the 15 months groups (p= 0,0001) and 30286,75+ 8321 cells/mm3and 19994+ 3085,9 cells/mm3 (p= 0,0001) in the posterior stroma in the 3 months and in the 15 months groups respectively. The comparison between the average densities through the whole cornea showed statistically significant difference between the 3 months vs 15 months group and 3 months vs normals, but it was not statistically significant different between 15 months vs normals.

Conclusions: : The changes in the corneal keratocyte population after LASEK + MMC seen in the early post-op, seem to change towards the normal values 15 months after the procedure.

Keywords: cornea: stroma and keratocytes • refractive surgery: other technologies • drug toxicity/drug effects 

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