March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
The Infant Aphakia Treatment Study (IATS): Axial Length Change Following Cataract Surgery at Age 1-6 Months
Author Affiliations & Notes
  • Scott R. Lambert
    Emory University, Atlanta, Georgia
  • Michael J. Lynn
    Emory University, Atlanta, Georgia
  • George A. Cotsonis
    Emory University, Atlanta, Georgia
  • E. Eugenie Hartmann
    Department of Optometry, Univ of Alabama at Birmingham, Birmingham, Alabama
  • Infant Aphakia Treatment Study Group
    Emory University, Atlanta, Georgia
  • Footnotes
    Commercial Relationships  Scott R. Lambert, None; Michael J. Lynn, None; George A. Cotsonis, None; E. Eugenie Hartmann, None
  • Footnotes
    Support  NIH U10 EY13272 and U10 EY013287 and in part by NIH Departmental Core Grant EY06360 and Research to Prevent Blindness, Inc, New York, New York
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2736. doi:
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      Scott R. Lambert, Michael J. Lynn, George A. Cotsonis, E. Eugenie Hartmann, Infant Aphakia Treatment Study Group; The Infant Aphakia Treatment Study (IATS): Axial Length Change Following Cataract Surgery at Age 1-6 Months. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2736.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To compare axial length elongation following cataract surgery with or without intraocular lens (IOL) implantation for infants with a unilateral congenital cataract .

Methods: : The Infant Aphakia Treatment Study (IATS) is a randomized, multicenter clinical trial comparing IOL to contact lens (CL) treatment for infants with a unilateral congenital cataract undergoing cataract surgery when 1 to 6 months of age. Axial length was measured at the time of cataract surgery and at approximately 1 year of age. A-scan tracings were reviewed by an echographer and measurements were excluded if the tracings were unavailable, unreadable or invalid. The change in axial length (mm/month) was related to treatment (IOL vs CL), eye (treated eye vs untreated eye) and age at surgery using a linear mixed model with treatment as a between subject factor, eye as a within subject factor and age at surgery as a covariate. Separate models for treated and untreated eyes were also fit. Reported means are least squares means.

Conclusions: : There was a reduction in axial elongation in aphakic, but not pseudophakic eyes compared to their fellow phakic eyes. Age at surgery was significantly related to change in axial length per month in phakic but not in aphakic or pseudophakic eyes.

Clinical Trial: : NCT00212134

Keywords: visual development: infancy and childhood • refractive error development • emmetropization 

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