April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Overview of Progress on the Boston Retinal Prosthesis
Author Affiliations & Notes
  • Joseph F. Rizzo, III
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    VA Healthcare System, Center for Innovative Visual Rehabilitation, Boston, Massachusetts
  • Jinghua Chen
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
  • Douglas B. Shire
    VA Healthcare System, Center for Innovative Visual Rehabilitation, Boston, Massachusetts
  • Shawn Kelly
    VA Healthcare System, Center for Innovative Visual Rehabilitation, Boston, Massachusetts
    Massachusetts Institute of Technology, Cambridge, Massachusetts
  • William D. Eldred
    Biology, Boston University, Boston, Massachusetts
  • William K. Jones
    Florida International University, Miami, Florida
  • Philip R. Troyk
    Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois
  • Patrick Doyle
    VA Healthcare System, Center for Innovative Visual Rehabilitation, Boston, Massachusetts
  • Marcus D. Gingerich
    VA Healthcare System, Center for Innovative Visual Rehabilitation, Boston, Massachusetts
    Cornell Nanofabrication Facility, Ithaca, New York
  • John L. Wyatt, Jr.
    Electrical Engineering, Massachusetts Inst of Technology, Cambridge, Massachusetts
  • Footnotes
    Commercial Relationships  Joseph F. Rizzo, III, None; Jinghua Chen, None; Douglas B. Shire, None; Shawn Kelly, None; William D. Eldred, None; William K. Jones, None; Philip R. Troyk, None; Patrick Doyle, None; Marcus D. Gingerich, None; John L. Wyatt, Jr., None
  • Footnotes
    Support  VA Grant C4266C, VA Grant A7078R, VA Grant C7055L, NIH Grants 1-R01-HL090856-01A1 and EY016674, Massachusetts Lions Eye Research Fund
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2593. doi:https://doi.org/
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      Joseph F. Rizzo, III, Jinghua Chen, Douglas B. Shire, Shawn Kelly, William D. Eldred, William K. Jones, Philip R. Troyk, Patrick Doyle, Marcus D. Gingerich, John L. Wyatt, Jr.; Overview of Progress on the Boston Retinal Prosthesis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2593. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

This work is related to the efforts of the Boston Retinal ImplantProject to develop a sub-retinal prosthesis to restore visionto the blind. The goal of this presentation is to provide anoverview of the status of the emerging, Boston-based, human-qualityretinal prosthesis.

 
Methods:
 

The Boston device includes a custom-designed ASIC and a hermeticTi case to support 200+ channels. Elements have been testedin vitro, and the entire embodiment has been implanted into3 mini-pigs, following 20 implant surgeries of our former 16-channeldevice. Custom surgical tools were developed for the new implants.

 
Results:
 

The ASIC is in final layout, and human safety protocols weredeveloped. The hermetic package for the device is complete.In vivo testing results show the secondary receiving coil isless susceptible to erosion than previously observed, and thetitanium case is well tolerated. A modified 2-step array insertionprocess also evolved to increase the flexibility of array placement.

 
Conclusions:
 

Advancements in circuit design, packaging, and surgical toolsand technique have put the development of the 200+ channel Bostonretinal prosthesis on pace for in vivo validation of functionby late 2011.  

 

 
Keywords: retina • neuro-ophthalmology: cortical function/rehabilitation • quality of life 
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