March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Resveratrol: Potential Drug For Treating Uveitis And Other Autoimmune Disease
Author Affiliations & Notes
  • Sung-Hye Kim
    Lab of Immunology, NEI, Bethesda, Maryland
  • Da-Young Ko
    Lab of Immunology, NEI, Bethesda, Maryland
  • Jenna Burton
    Lab of Immunology, NEI, Bethesda, Maryland
  • Cheng-Rong Yu
    Lab of Immunology, NEI, Bethesda, Maryland
  • Charles Egwuagu
    Lab of Immunology, NEI, Bethesda, Maryland
  • Footnotes
    Commercial Relationships  Sung-Hye Kim, None; Da-Young Ko, None; Jenna Burton, None; Cheng-Rong Yu, None; Charles Egwuagu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2761. doi:
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      Sung-Hye Kim, Da-Young Ko, Jenna Burton, Cheng-Rong Yu, Charles Egwuagu; Resveratrol: Potential Drug For Treating Uveitis And Other Autoimmune Disease. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2761.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Experimental autoimmune uveitis (EAU) is a T cell mediated inflammatory disease that shares essential pathological features with human uveitis and serves as a mouse model of posterior uveitis. Th17 and Th1 cells have been implicated in the etiology of uveitis and suppressing the expansion of these CD4+ T cell subsets during uveitis may be therapeutically beneficial. Resveratrol is an antioxidant polyphenols contained in red wine and grape skin and has been shown to possess anti-inflammatory properties. In this study, we investigated whether Resveratrol might inhibit the expansion of uveitogenic T cells and ameliorate EAU.

Methods: : The naïve CD4 T cells from C57BL/6 mice were isolated and cultured under Th1 or Th17 polarization condition in the presence or absence of Resveratrol. Cellular proliferation/expansion was determined by the antigen-induced CD154 expression assay, 3H-thymidine incorporation or CFSE labeling assay. Gene expression was analyzed by RT-PCR and quantified by qPCR. Intracellular cytokine expression was detected by FACS analysis and effects of Resveratrol on cell survival was determined by Annexin-V staining assay. EAU was induced by adoptive transfer of IRBP-specific pathogenic T cells and effects of Resveratrol on development and severity of EAU was monitored by fundoscopy or histopathology.

Results: : Resveratrol suppressed the differentiation of Th17 and Th1 cells and inhibited the expansion of uveitogenic Th17 cells during EAU. Resveratrol inhibited adoptive transfer of uveitis to syngeneic mice.

Conclusions: : Resveratrol could potentially be a safe and effective drug for treating uveitis and other autoimmune disease.

Keywords: autoimmune disease • immunomodulation/immunoregulation • inflammation 

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