April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Miniaturized High-intensity Focused Ultrasound Device For The Treatment Of Glaucoma: A Clinical Pilot Study
Author Affiliations & Notes
  • Philippe M. Denis
    Ophthalmology, Hospital Croix Rousse, Lyon, France
  • Florent Aptel
    Ophthalmology, Hospital Edouard Herriot, Lyon, France
  • Thomas Charrel
    U 556, INSERM, Lyon, France
  • Cyril Lafon
    U 556, INSERM, Lyon, France
  • Jean-Yves Chapelon
    U 556, INSERM, Lyon, France
  • Jean-Philippe Nordmann
    Ophthalmology, Hopital des Quinze Vingts, PARIS, France
  • Footnotes
    Commercial Relationships  Philippe M. Denis, EyeTechCare (C); Florent Aptel, EyeTechCare (C); Thomas Charrel, EyeTechCare (F); Cyril Lafon, EyeTechCare (F); Jean-Yves Chapelon, EyeTechCare (F); Jean-Philippe Nordmann, EyeTechCare (C)
  • Footnotes
    Support  EyeTechCare Grant
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2648. doi:
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      Philippe M. Denis, Florent Aptel, Thomas Charrel, Cyril Lafon, Jean-Yves Chapelon, Jean-Philippe Nordmann; Miniaturized High-intensity Focused Ultrasound Device For The Treatment Of Glaucoma: A Clinical Pilot Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2648.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the safety and efficacy of high-intensity focused ultrasound delivered by miniaturized annular transducers in patients with refractory glaucoma.

Methods: : Eight eyes of 8 patients with refractory glaucoma and uncontrolled intraocular pressure (IOP) were insonified using a ring comprising a six-sector transducer. UBM and a complete ophthalmic examination were performed before the procedure, and at 1 day, 1 week, 1, 3 and 6 months after the procedure. Main outcomes measures: Intraocular pressure reduction and intra- or post-operative complications.

Results: : Intraocular pressure (IOP) was reduced from a mean preoperative value of 36.2 ± 7.4 mmHg (n= 2.9 glaucoma medications) to a mean postoperative value of 26.5 ± 5.7 (n=2.7), 24.8 ± 9.9 (n=2.7), 26.9 ± 6.6 (n=3.0), 29.6 ± 8.5 mmHg (n=2.8) and 25.2 ± 14.8 mmHg (n=2.8) at 1 day, 1 week, 1, 3 and 6 months respectively. No major intra- or post-operative complications occurred. UBM showed cystic involution of the ciliary body in 6 of the 8 eyes, and a suprachoroidal fluid space in 2 of the 8 eyes.

Conclusions: : Ultrasonic coagulation of the ciliary body using high-intensity focused ultrasound delivered by a circular miniaturized transducer seems to be a promising and well-tolerated method to reduce IOP in patients with refractory glaucoma.

Clinical Trial: : French Health Authority AFSSAPS, 2009-A01132-55

Keywords: intraocular pressure • ciliary body 
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