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Ugo Introini, Marco Gagliardi, Casalino Giuseppe, Pierro Luisa, Marco Setaccioli, Fabrizio Scotti, Silvia M. Giatsidis, Francesco M. Bandello; Spectral-Domain Optical Coherence Tomography of Myopic Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2707.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate macular morphology in eyes with choroidal neovascularization (CNV) in high myopia treated with anti-VEGF therapy using Spectral Domain Optical Coherence Tomography (SDOCT).
Nineteen eyes of 19 consecutive patients with recent-onset CNV, active at fluorescein angiography were included. SDOCT line foveal scans were obtained at baseline and after treatment. The OCT parameters considered were the integrity of the retinal outer lines, corresponding to the External Limiting Membrane (ELM), IS/OS junction, RPE, as well as the pathologic findings, i.e. hypereflective areas, hyporeflective fluid and vitreoretinal alterations.
At baseline, the scans corresponding to the CNV showed a hyperreflective area, with fuzzy borders and a more highly-refective core above the RPE was observed in almost all eyes (18/19). The IS/OS line was not detectable in 17 out of 19 eyes. A slight amount of subretinal fluid was present in two eyes, and in another two as intraretinal cystic spaces. Mean baseline Visual Acuity was 0.54 logMAR (20/69), sd 0.33, and final was 0.35 logMAR (20/45), sd 0.33. VA increased in 14 eyes, was stable in four and got worse in one. Following treatment, the blurred hyperreflective areas disappeared in 17 eyes, yet were still slightly visible in two. The RPE was thicker in nine eyes, and in six was associated with a highly-reflectant subretinal well-defined tissue. Subretinal fluid was still present in two eyes, and intraretinal cysts in one.
SDOCT morphology of active myopic CNV shows a common pattern, characterized by hyperreflective areas, rarely associated with subretinal fluid and well responsive to antiangiogenic treatment. Further investigation is needed to improve our knowledge on the antiangiogenic treatment of myopic CNVs.
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