April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Rate of Myopia Progression in Chinese Children is Slower in Summer than in Winter
Author Affiliations & Notes
  • Leslie A. Donovan
    Brien Holden Vision Institute, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • Padmaja Sankaridurg
    Brien Holden Vision Institute, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • Judith Kwan
    Brien Holden Vision Institute, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • Xiang Chen
    Vision Cooperative Research Centre, Sydney, Australia
    International Clinical trials Center, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
  • Arthur Ho
    Brien Holden Vision Institute, Sydney, Australia
    School of Optometry & Vision Science, UNSW, Sydney, Australia
  • Earl L. Smith, III
    College of Optometry, University of Houston, Texas
  • Percy Lazon
    Brien Holden Vision Institute, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • Brien A. Holden
    Brien Holden Vision Institute, Sydney, Australia
    School of Optometry & Vision Science, UNSW, Sydney, Australia
  • Jian Ge
    International Clinical trials Center, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
  • Footnotes
    Commercial Relationships  Leslie A. Donovan, None; Padmaja Sankaridurg, None; Judith Kwan, None; Xiang Chen, None; Arthur Ho, None; Earl L. Smith, III, None; Percy Lazon, None; Brien A. Holden, None; Jian Ge, None
  • Footnotes
    Support  Brien Holden Vision Institute; Vision CRC
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2713. doi:
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      Leslie A. Donovan, Padmaja Sankaridurg, Judith Kwan, Xiang Chen, Arthur Ho, Earl L. Smith, III, Percy Lazon, Brien A. Holden, Jian Ge; The Rate of Myopia Progression in Chinese Children is Slower in Summer than in Winter. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2713.

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Abstract

Purpose: : To characterize seasonal variations in myopic progression in Chinese children

Methods: : Data are presented for 98 children who wore single-vision spectacles in two clinical trials conducted at Zhongshan Ophthalmic Center for the Vision CRC Myopia Control Study. Children were 6-16 yrs old in the first trial and 6 to 12 yrs in the second. Refractive error and axial length data were obtained 6-monthly by cycloplegic autorefraction and partial coherence interferometry respectively. Progression rates were defined for the first and second 6 months of the 12 months studied. Data were classified in terms of summer, winter or other months, based on the mid-month of the 6-month period between visits; June through September as summer; December through March as winter. Guangzhou has 8 weeks of summer school holidays during July/August and one month of winter holidays during January/February.

Results: : The mean 6-month spherical equivalent progressions were -0.25±0.24D, -0.42±0.24D, and -0.57±0.33D for summer, other, and winter months, respectively (p<0.001) and for axial elongation 0.12± 0.11mm, 0.20±0.11mm and 0.25±0.12mm (p<0.001). Post-hoc analysis showed data for each season were different to each other at the p=0.05 level, with the exception of axial length for other months versus summer (p=0.085).

Conclusions: : The children exhibited less than half the myopia progression and axial elongation in summer months as they did in winter. These results demonstrate the importance of taking into account the time of year when conducting studies of myopia progression and clinical trials of potential treatment strategies for myopia. Ambient light levels and higher levels of outdoor activities in summer versus winter may be contributing factors to these substantial differences in rates of myopia increase and their relative influences need to be determined.

Clinical Trial: : ChiCTR, TRC 00000029

Keywords: myopia 
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