April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Correlation Between Fluorescein Angiography And Spectral Domain Optical Coherence Tomography For Monitoring Anti-vegf Therapy In Choroidal Neovascularization Secondary To Pathologic Myopia
Author Affiliations & Notes
  • Pierluigi Iacono
    Eye Clinic, Fondazione GB Bietti, IRCCS, Rome, Rome, Italy
  • Maurizio B. Parodi
    Department of Ophthalmology, Scientific Institute San Raffaele, Milano, Italy
  • Alessandro Papayannis
    Department of Ophthalmology, Scientific Institute San Raffaele, Milano, Italy
  • Ilaria Zucchiatti
    Department of Ophthalmology, Scientific Inst San Raffaele, Milan, Milano, Italy
  • Marialucia Cascavilla
    University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy
  • Dimitrios Stylianos Kontadakis
    Department of Ophthalmology, Melegnano Hospital Milano Italy, Vizzolo Predabissi Milano, Italy
  • Francesco Bandello
    Ophthalmology, Univ Vita Salute - San Raffaele, Milan, Italy
  • Footnotes
    Commercial Relationships  Pierluigi Iacono, None; Maurizio B. Parodi, None; Alessandro Papayannis, None; Ilaria Zucchiatti, None; Marialucia Cascavilla, None; Dimitrios Stylianos Kontadakis, None; Francesco Bandello, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2719. doi:https://doi.org/
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      Pierluigi Iacono, Maurizio B. Parodi, Alessandro Papayannis, Ilaria Zucchiatti, Marialucia Cascavilla, Dimitrios Stylianos Kontadakis, Francesco Bandello; Correlation Between Fluorescein Angiography And Spectral Domain Optical Coherence Tomography For Monitoring Anti-vegf Therapy In Choroidal Neovascularization Secondary To Pathologic Myopia. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2719. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the agreement between fluorescein angiography (FA) and spectral domain optical coherence tomography (SD-OCT) in detecting the activity of myopic choroidal neovascularization (CNV) during the treatment with intravitreal bevacizumab injection (IVBI).

Methods: : Patients affected by myopic subfoveal CNV were prospectively enrolled in the study; at baseline and at all planned monthly visit, each patient underwent a complete ophthalmological examination, including BCVA assessment on ETDRS charts, slit lamp examination, FA and SD-OCT examination. After the first IVBI (1.25mg), additional injections were performed on the basis of the detection of any type of fluid on SD-OCT and/or presence of leakage or progression on FA. Inter-rater agreement kappa analysis was performed to examine the concordance between FA and SD-OCT in assessing CNV activity. Moreover, considering FA as standard reference examination, sensitivity and specificity were calculated.

Results: : Thirty-four eyes were included in the study. At the baseline, FA and SD-OCT achieved an agreement in 26/34 cases (X%) with a k value of 0.23; sensitivity and specificity were respectively 77.4 and 66.7. The remaining eight cases, 7 eyes presented leakage on FA and absence of fluid on SD-OCT examination, whereas 1 case showed intraretinal fluid on SD-OCT and absence of leakage on FA. At 1-month examination, specificity and K value improved and a concordance was reached in 30/34 cases. At 3- and 4-month examination a discordance was noted in 6 case and the k values were 0.60 and 0.51, respectively. From 5-month examination on, a consensus was achieved in at least 30/34 cases (88%) and reached a complete agreement in 9 sessions.

Conclusions: : The present study reveals that FA still plays a main role in the diagnosis of CNV in myopic eyes. However, it seems possible to hypothesize a role of SD-OCT for monitoring the anti-VEGF treatment over the follow-up.

Keywords: choroid: neovascularization • myopia • vascular endothelial growth factor 
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