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Bianca C. Dobner, Regina Max, Matthias Becker, Friederike Mackensen; Enhanced Depth Imaging Patterns With The Spectralis OCT In Patients With Posterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2723.
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The purpose of this study was to compare the fluorescein/indocyaninegreen (FAG/ICG) angiography with the features corresponding to the spectral-domain optical coherence tomography (SD-OCT) using the technique of enhanced depth imaging (EDI).
We included 23 patients, who were treated at the uveitis center Heidelberg for posterior uveitis like serpiginous choroiditis, birdshot chorioretinopathy, sarcoidosis or toxoplasmosis. They underwent FAG/ICG angiography and SD-OCT EDI (Heidelberg Engeneering, Germany) scans since September 2010. The scans were evaluated by two different experienced readers in regard to choroidal thickness/thinning and RPE changes.
Up till now we examined twenty-one eyes of 16 different patients (6 male and 10 female) showing leakage or (multi-)focal staining in the angiography, due to posterior uveitis. The already evaluated results showed in 6 eyes a discrete focal hyperfluorescence (focal staining) in the angiography with associated thinning of the choroid and focal atrophy of the retinal pigment epithelium (RPE) in the corresponding EDI OCT. 5 eyes showed a typical "hot spot" in the late angiography (focal leakage) with a focal RPE break in the corresponding EDI OCT in 3 eyes and a serous RPE detachment in 2 eyes.
An active posterior uveitis can be recognized due to a leakage in FAG/ICG, but also due to morphological changes of the choroid. In this study it was shown that using the Spectralis EDI OCT gives more information about the state of inflammation in the choroid and changes like atrophy or thinning.
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