April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Choroidal Thickness in Birdshot Chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography
Author Affiliations & Notes
  • Avnish A. Deobhakta
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Thomas Albini
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Fouad El Sayyad
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Janet Davis
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • William Feuer
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • Footnotes
    Commercial Relationships  Avnish A. Deobhakta, None; Thomas Albini, None; Fouad El Sayyad, None; Janet Davis, None; William Feuer, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2727. doi:
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      Avnish A. Deobhakta, Thomas Albini, Fouad El Sayyad, Janet Davis, William Feuer; Choroidal Thickness in Birdshot Chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2727.

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Abstract
 
Purpose:
 

To measure choroidal thickness at different points using EDI-OCTin patients with documented Birdshot Chorioretinopathy

 
Methods:
 

Methods: EDI-OCT images were obtained in using the HeidelbergOCT (spectral-domain OCT) in 18 patients. The choroid was measuredfrom the outer border of the RPE to the inner scleral borderat 1 mm intervals of a horizontal section from 2 mm temporalto the fovea to 2 mm nasal to the fovea. A retrospective chartreview was also done for each patient for which duration ofuveitis, immunomodulating therapy (in particular those withfluocinolone acetonide intravitreal/Retisert implants), visualacuity, and IOP were also obtained. Choroidal measurements wereaveraged between both eyes.

 
Results:
 

Patients with BCR demonstrated thicker choroidal measurementsearly in the course of disease (greater than 300 microns --See Figure 1) than previously established normals (287 microns).This relationship reversed (less than 200 microns) later inthe disease. There was an inverse correlation between age andchoroidal thickness (r squared = 0.51, p-value = 0.009). Therewas an inverse correlation between patients without the fluocinoloneacetonide intravitreal/Retisert implant (11 total patients)and duration of uveitis (r squared = 0.75, p-value < 0.001).This correlation was not found with those without the implant.

 
Conclusions:
 

Patients with BCR have choroidal thicknesses that differ frompreviously established norms in the literature. This variancemight be explained by the duration of uveitis and age. In addition,patients with immunomodulating therapy such as the Retisertimplant may alter choroidal thickness.  

 

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • choroid • uveitis-clinical/animal model 
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