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Avnish A. Deobhakta, Thomas Albini, Fouad El Sayyad, Janet Davis, William Feuer; Choroidal Thickness in Birdshot Chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2727.
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To measure choroidal thickness at different points using EDI-OCTin patients with documented Birdshot Chorioretinopathy
Methods: EDI-OCT images were obtained in using the HeidelbergOCT (spectral-domain OCT) in 18 patients. The choroid was measuredfrom the outer border of the RPE to the inner scleral borderat 1 mm intervals of a horizontal section from 2 mm temporalto the fovea to 2 mm nasal to the fovea. A retrospective chartreview was also done for each patient for which duration ofuveitis, immunomodulating therapy (in particular those withfluocinolone acetonide intravitreal/Retisert implants), visualacuity, and IOP were also obtained. Choroidal measurements wereaveraged between both eyes.
Patients with BCR demonstrated thicker choroidal measurementsearly in the course of disease (greater than 300 microns --See Figure 1) than previously established normals (287 microns).This relationship reversed (less than 200 microns) later inthe disease. There was an inverse correlation between age andchoroidal thickness (r squared = 0.51, p-value = 0.009). Therewas an inverse correlation between patients without the fluocinoloneacetonide intravitreal/Retisert implant (11 total patients)and duration of uveitis (r squared = 0.75, p-value < 0.001).This correlation was not found with those without the implant.
Patients with BCR have choroidal thicknesses that differ frompreviously established norms in the literature. This variancemight be explained by the duration of uveitis and age. In addition,patients with immunomodulating therapy such as the Retisertimplant may alter choroidal thickness.
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