Purchase this article with an account.
Juliana L. Orefice, Rogerio A. Costa, Sr., Ingrid U. Scott, Daniela Calucci, Fernando Orefice, Sr., MINAS Research Group; Multimodal Fundus Imaging In Active Ocular Toxoplasmosis: Baseline Characteristics And Spectral Optical Coherence Tomography Findings. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2750.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To characterize the active retinochoroiditis lesion observed in patients with the classic clinical presentation of ocular toxoplasmosis (OT) utilizing spectral optical coherence tomography (SOCT).
Twenty-four patients with OT based on the classical clinical findings of an active focus of retinochoroiditis adjacent to a pigmented chorioretinal scar and positive serum toxoplasmosis IgG titers were included. Each patient underwent standardized ophthalmologic examination and multimodal fundus imaging, including SOCT evaluation.
The mean age of the fourteen (58.3%) women and ten (41.7%) men was 27.6 ± 12.4 years. The mean ETDRS best-corrected visual acuity was 20/80-1. On SOCT evaluation, the posterior hyaloid was thickened in 95.8%. Increased hyper-reflective signals in the vitreous were observed in 75.0%. Vitreal spherical hyper-reflective depositions were observed in 50.0%. In all patients, at the active OT lesion site, the inner retinal layers were abnormally hyper-reflective with full-thickness disorganization of the retinal reflective layers (smudge effect) and some degree of choriocapillaris/choroidal optical shadowing. The retina was thickened at the active lesion site in 87.5%. The RPE-Bruch membrane reflective complex was focally increased or contained focal splits in 66.7%. Disorganization of the outer retinal highly reflective layers adjacent to the active OT lesion was observed in all patients.
The active OT lesion affected the inner retina with full-thickness disorganization of the retinal layers and some degree of choriocapillaris/choroidal optical shadowing in all patients. Adjacent to the lesion, the outer retina was consistently altered and the posterior hyaloid was thickened in all but one patient.
This PDF is available to Subscribers Only