April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Risk Factors For Retinal Neovascularization In Patients With Uveitis
Author Affiliations & Notes
  • Apurva K. Patel
    Ophthalmology, Uveitis Clinic/Portland VAMC,
    University of Pennsylvania / Scheie Eye Institute, Philadelphia, Pennsylvania
  • Craig W. Newcomb
    Biostatistics & Epidemiology, Ophthalmology & Rheumatology,
    University of Pennsylvania / Scheie Eye Institute, Philadelphia, Pennsylvania
  • Eric B. Suhler
    Ophthalmology, Uveitis Clinic/Portland VAMC,
    Casey Eye Institute-OHSU, Portland, Oregon
  • Jennifer E. Thorne
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • C Stephen Foster
    Ophthalmology, Ocular Immunology and Uveitis Foundation, Cambridge, Massachusetts
  • Douglas A. Jabs
    Ophthalmology and Medicine, Mount Sinai School of Medicine, New York, New York
  • Grace A. Levy-Clarke
    St Lukes Cataract and Laser Institute, St Petersburg, Florida
  • Robert B. Nussenblatt
    National Eye Inst/NIH, Bethesda, Maryland
  • James T. Rosenbaum
    Biostatistics & Epidemiology, Ophthalmology & Rheumatology,
    Casey Eye Institute-OHSU, Portland, Oregon
  • John H. Kempen
    Ophthalmology, Uveitis Clinic/Portland VAMC,
    Biostatistics & Epidemiology, Ophthalmology & Rheumatology,
    University of Pennsylvania / Scheie Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Apurva K. Patel, None; Craig W. Newcomb, None; Eric B. Suhler, None; Jennifer E. Thorne, None; C Stephen Foster, None; Douglas A. Jabs, None; Grace A. Levy-Clarke, None; Robert B. Nussenblatt, None; James T. Rosenbaum, None; John H. Kempen, None
  • Footnotes
    Support  Funded primarily by National Eye Institute Grant EY014943, additional support from Research to Prevent Blindness and the Mackall Foundation.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2756. doi:
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    • Get Citation

      Apurva K. Patel, Craig W. Newcomb, Eric B. Suhler, Jennifer E. Thorne, C Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, John H. Kempen; Risk Factors For Retinal Neovascularization In Patients With Uveitis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2756.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the risk of retinal neovascularization (NV) in patients with uveitis and evaluate potential risk factors and associated features.

Methods: : Retrospective cohort study of patients with uveitis at five academic ocular inflammation subspeciality practices. Data were ascertained by standardized chart review. Incidence data were analyzed using survival analysis with time-updated covariates where appropriate.

Results: : 95/8771 patients presenting for initial evaluation had NV giving a prevalence of 1.1%. 79 patients developed NV over 15522.84 person-years for an incidence of 0.51% per person-year. Factors associated with incident NV include age <35 as compared to >35 years (crude hazard ratio (HR) = 1.76, 95% confidence interval 1.1-2.7), bilateral inflammation (2.6; 1.3-5.4), and diagnosis of uveitis within the last 5 years as compared to >5 years (2.3; 1.2-4.4). As compared to anterior uveitis, intermediate uveitis carried a crude HR of 4.4 (2.2-8.7), posterior uveitis 5.1 (2.5-10), and panuveitis 5.3 (2.6-11). Patients with retinal NV were more likely to have retinal vascular occlusions (15; 4.6-57), retinal vascular sheathing (4.2; 2.3-7.7), and exudative retinal detachment (5.1; 1.6-16). Systemic lupus erythematosus also was associated with NV (4.3; 1.6-12). The presence of currently active inflammation was weakly associated as compared to inactive inflammation (1.6; 0.95-2.6).

Conclusions: : Retinal NV is a rare but vision-threatening complication of uveitis, which occurs more frequently in cases with more posterior disease and involvement of the retinal vascular system. Our results suggest that controlling inflammation might help to avoid this serious complication.

Keywords: retinal neovascularization • inflammation • autoimmune disease 

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