Purchase this article with an account.
David W. Li, Jin-Ping Li, Mi Deng, Lili Gong, Wei-Ke Ji, Haili Ma, Pei-Qiao Chen, Xiao-Hui Hu, Wen-Bin Liu, Ya-Mei Xiao; Protein Serine/threonine Phosphatase-1 Regulates A Signaling Network To Control Lens Differentiation And Pathogenesis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2786.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Our previous studies have shown that protein serine/threonine phosphatase-1 is a major phosphatase in the ocular lens. Inhibition of PP-1 activity leads to apoptosis of lens epithelial cells followed by cataractogenesis. However, how PP-1 regulates various signaling network components to control lens development and pathogenesis need to be elucidated.
Various lines of mice and lens epithelial cells were used as assay systems. Both in vitro and in vivo molecular and cellular biology techniques were used to explore the signaling components under regulation by PP-1.
PP-1 directly dephosphorylates p53, Pax-6, Akt and other signaling components to exert control on lens cell proliferation, differentiation, apoptosis and senescence to control lens development and pathogenesis.
PP-1 regulates a signaling network to control lens development and pathogenesis.
This PDF is available to Subscribers Only