April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Protein Serine/threonine Phosphatase-1 Regulates A Signaling Network To Control Lens Differentiation And Pathogenesis
David W. Li; Jin-Ping Li; Mi Deng; Lili Gong; Wei-Ke Ji; Haili Ma; Pei-Qiao Chen; Xiao-Hui Hu; Wen-Bin Liu; Ya-Mei Xiao
Author Affiliations & Notes
  • David W. Li
    Biochemistry & Molecular Biology,
    Ophthalmology & Visual Sciences,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Jin-Ping Li
    Biochemistry & Molecular Biology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Mi Deng
    Biochemistry & Molecular Biology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Lili Gong
    Biochemistry & Molecular Biology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Wei-Ke Ji
    Biochemistry & Molecular Biology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Haili Ma
    Biochemistry & Molecular Biology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Pei-Qiao Chen
    Key Lab. of Protein Chemistry & Developmental Biology, Hunan Normal University, Changsha, Hunan 410081, China
  • Xiao-Hui Hu
    Key Lab. of Protein Chemistry & Developmental Biology, Hunan Normal University, Changsha, Hunan 410081, China
  • Wen-Bin Liu
    Key Lab. of Protein Chemistry & Developmental Biology, Hunan Normal University, Changsha, Hunan 410081, China
  • Ya-Mei Xiao
    Key Lab. of Protein Chemistry & Developmental Biology, Hunan Normal University, Changsha, Hunan 410081, China
  • Footnotes
    Commercial Relationships  David W. Li, None; Jin-Ping Li, None; Mi Deng, None; Lili Gong, None; Wei-Ke Ji, None; Haili Ma, None; Pei-Qiao Chen, None; Xiao-Hui Hu, None; Wen-Bin Liu, None; Ya-Mei Xiao, None
  • Footnotes
    Support  1R01EY015765; 1R01EY018380
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2786. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Protein Serine/threonine Phosphatase-1 Regulates A Signaling Network To Control Lens Differentiation And Pathogenesis
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      David W. Li, Jin-Ping Li, Mi Deng, Lili Gong, Wei-Ke Ji, Haili Ma, Pei-Qiao Chen, Xiao-Hui Hu, Wen-Bin Liu, Ya-Mei Xiao; Protein Serine/threonine Phosphatase-1 Regulates A Signaling Network To Control Lens Differentiation And Pathogenesis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2786.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Our previous studies have shown that protein serine/threonine phosphatase-1 is a major phosphatase in the ocular lens. Inhibition of PP-1 activity leads to apoptosis of lens epithelial cells followed by cataractogenesis. However, how PP-1 regulates various signaling network components to control lens development and pathogenesis need to be elucidated.

Methods: : Various lines of mice and lens epithelial cells were used as assay systems. Both in vitro and in vivo molecular and cellular biology techniques were used to explore the signaling components under regulation by PP-1.

Results: : PP-1 directly dephosphorylates p53, Pax-6, Akt and other signaling components to exert control on lens cell proliferation, differentiation, apoptosis and senescence to control lens development and pathogenesis.

Conclusions: : PP-1 regulates a signaling network to control lens development and pathogenesis.

Keywords: cataract • protein modifications-post translational • signal transduction 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept