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Prethy Rao, Amy E. Millen, Rickie Voland, Sherie A. Sondel, Leslie Tinker, Robert Wallace, Julie A. Mares; The Relationship Between Serum Vitamin D Levels And Nuclear Cataract In A Carotenoid Age-related Eye Study (careds), An Ancillary Study Of The Women's Health Initiative. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2794.
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To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of nuclear opacities and cataract among participants of the Carotenoids in Age-Related Eye Disease Study(CAREDS), an ancillary study of the Women’s Health Initiative (WHI).
In 1,276 postmenopausal women, nuclear cataract was assessed from slit lamp photographs taken from 2001-2004. Serum 25(OH)D levels were assessed at WHI baseline (1994-1998). Age-adjusted and multivariate (age, iris color, smoking, pulse pressure) adjusted odds ratios (OR) and 95% confidence intervals (95% CIs) for nuclear cataract (nuclear opacities > level 4 and cataract extraction) by quintiles of 25(OH)D were estimated using logistic regression.
No significant association was observed between 25(OH)D and nuclear cataract among women of all ages (Age-adjusted OR [95%CI] = 1.0 [0.6-1.4]). However, there was a significant age interaction (p for interaction = 0.04) in women 70 years.
High serum 25(OH)D levels may be protective against nuclear opacities in women aged <70, and explained by predictors of serum vitamin D and a systemic marker of inflammation.
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