April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
The Relationship Between Serum Vitamin D Levels And Nuclear Cataract In A Carotenoid Age-related Eye Study (careds), An Ancillary Study Of The Women's Health Initiative
Author Affiliations & Notes
  • Prethy Rao
    University of Wisconsin Medical School, Middleton, Wisconsin
  • Amy E. Millen
    Social and Preventive Medicine, University at Buffalo, Buffalo, New York
  • Rickie Voland
    University of Wisconsin, Madison, Wisconsin
  • Sherie A. Sondel
    Opthalmology & Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin
  • Leslie Tinker
    Fred Hutchinson Cancer Research Center, Seattle, Washington
  • Robert Wallace
    University of Iowa, Iowa City, Iowa
  • Julie A. Mares
    Ophthal and Visual Sci, Univ of Wisconsin-Madison, Madison, Wisconsin
  • Footnotes
    Commercial Relationships  Prethy Rao, None; Amy E. Millen, None; Rickie Voland, None; Sherie A. Sondel, None; Leslie Tinker, None; Robert Wallace, None; Julie A. Mares, None
  • Footnotes
    Support  NIH, NEI R01 EY016886 and 13018, the Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2794. doi:
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      Prethy Rao, Amy E. Millen, Rickie Voland, Sherie A. Sondel, Leslie Tinker, Robert Wallace, Julie A. Mares; The Relationship Between Serum Vitamin D Levels And Nuclear Cataract In A Carotenoid Age-related Eye Study (careds), An Ancillary Study Of The Women's Health Initiative. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2794.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of nuclear opacities and cataract among participants of the Carotenoids in Age-Related Eye Disease Study(CAREDS), an ancillary study of the Women’s Health Initiative (WHI).

Methods: : In 1,276 postmenopausal women, nuclear cataract was assessed from slit lamp photographs taken from 2001-2004. Serum 25(OH)D levels were assessed at WHI baseline (1994-1998). Age-adjusted and multivariate (age, iris color, smoking, pulse pressure) adjusted odds ratios (OR) and 95% confidence intervals (95% CIs) for nuclear cataract (nuclear opacities > level 4 and cataract extraction) by quintiles of 25(OH)D were estimated using logistic regression.

Results: : No significant association was observed between 25(OH)D and nuclear cataract among women of all ages (Age-adjusted OR [95%CI] = 1.0 [0.6-1.4]). However, there was a significant age interaction (p for interaction = 0.04) in women 70 years.

Conclusions: : High serum 25(OH)D levels may be protective against nuclear opacities in women aged <70, and explained by predictors of serum vitamin D and a systemic marker of inflammation.

Keywords: cataract • nutritional factors • clinical (human) or epidemiologic studies: risk factor assessment 

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