April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Polarization Sensitive Optical Coherence Tomography Of The Human Retina At 840 nm And 1030 nm
Author Affiliations & Notes
  • Teresa Torzicky
    Medical University of Vienna, Vienna, Austria
  • Erich Götzinger
    Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Medical University of Vienna, Vienna, Austria
  • Stefan Zotter
    Medical University of Vienna, Vienna, Austria
  • Marco Bonesi
    Medical University of Vienna, Vienna, Austria
  • Christoph K. Hitzenberger
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Teresa Torzicky, None; Erich Götzinger, Canon (F); Michael Pircher, Canon (F); Stefan Zotter, None; Marco Bonesi, None; Christoph K. Hitzenberger, Canon (F)
  • Footnotes
    Support  project FUNOCT, FP7 HEALTH, contract no. 201880
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2863. doi:
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      Teresa Torzicky, Erich Götzinger, Michael Pircher, Stefan Zotter, Marco Bonesi, Christoph K. Hitzenberger; Polarization Sensitive Optical Coherence Tomography Of The Human Retina At 840 nm And 1030 nm. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2863.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare polarization sensitive optical coherence tomography (PS-OCT) system performances in the 840 nm and the 1030 nm wavelength region for imaging the human ocular fundus in vivo.

Methods: : For our comparison we used a spectrometer based PS-OCT system in the 840 nm wavelength region which has been presented previously and has been used for imaging of a variety of retinal diseases. Furthermore we developed a novel PS-OCT system working at a central wavelength of 1030 nm. Light in this wavelength region is less absorbed by the retinal pigment epithelium and therefore higher penetration depths in retinal imaging are achievable. Polarization characteristics of different layers of the ocular fundus were investigated using both systems. Intensity, retardation, fast axis orientation and degree of polarization uniformity values were calculated from the acquired data and the results were compared for the different PS-OCT systems.

Results: : Measurements on healthy human volunteers were performed with both instruments and 2D and 3D data sets of the fovea centralis and the optic nerve head were acquired. With both systems we were able to clearly visualize the retinal pigment epithelium and its depolarizing characteristics and the retardation caused by birefringent tissues like the retinal nerve fiber layer. The 840 nm system demonstrated a better resolution for the inner retinal layers compared to the 1030 nm system. Higher penetration depth and better visualization of choroid and sclera were shown with the 1030 nm set up.

Conclusions: : Both systems provided tissue specific contrast for retinal pigment epithelium and retinal nerve fiber layer. The 840 nm system was especially suited for anterior retinal layers down to the retinal pigment epithelium, while the 1030 nm system was superior for imaging deeper layers, down to the sclera.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
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