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Grant D. Aaker, Minhee Cho, Donald J. D'Amico, Szilard Kiss; Decreased Choroidal Thickness in Patients with Age-Related Macular Degeneration as Measured by Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2868.
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To compare choroidal thickness (CT) between patients with dryage-related macular degeneration (AMD) and matched controls.
Patients with dry AMD and matched controls underwent enhanceddepth imaging (EDI) optical coherence tomography (OCT). Horizontalsections through the fovea were analyzed with image analysissoftware from the OCT manufacturer. To measure CT, the outerborder of the retinal pigment epithelium and the inner borderof the sclera were manually segmented and the distance betweenthem was measured at 9 points at 500 micron intervals alonga 4 millimeter (mm) line centered on the fovea. Two-sampledt-test was used to determine differences in CT between the twogroups.
27 eyes from 17 patients with AMD (mean age 77, range 52-94)and 27 eyes from 24 matched controls (mean age 68, range 58-81)were included in the study. Mean CT was reduced at all 9 measuredpoints for dry AMD patients compared to controls, with 7 of9 points reaching significance (p <0.05). The two pointsfarthest nasal did not reach significance. Mean subfoveal CTwas 193 +/- 88.9 um in AMD patients compared to 259 +/- 96.1um in controls (p = 0.0118), indicating a 36% reduction.
EDI OCT showed a decrease in cross-sectional CT between patientswith AMD and matched controls at 9 points along a 4 mm horizontalsection through the fovea. Statistical significance was reachedat 7 of 9 points. Additionally, dry AMD patients in our studyalso demonstrated a 36% reduction in CT compared to previouslypublished formula for determining age-specific CT. These resultssupport a theory of choroidal abnormalities in the pathogenesisof AMD.
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