April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Distinction of Cone Outer Segment Tips and Foveal Disruption Artifacts in Spectral-Domain Optical Coherence Tomography Images of Normal Eyes
Author Affiliations & Notes
  • Tosho Rii
    Kyorin Eye Center, Kyorin University School of Medicine, Mitaka City, Tokyo, Japan
  • Yuji Itoh
    Kyorin Eye Center, Kyorin University School of Medicine, Mitaka City, Tokyo, Japan
  • Makoto Inoue
    Kyorin Eye Center, Kyorin University School of Medicine, Mitaka City, Tokyo, Japan
  • Akito Hirakata
    Kyorin Eye Center, Kyorin University School of Medicine, Mitaka City, Tokyo, Japan
  • Footnotes
    Commercial Relationships  Tosho Rii, None; Yuji Itoh, None; Makoto Inoue, None; Akito Hirakata, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2880. doi:
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      Tosho Rii, Yuji Itoh, Makoto Inoue, Akito Hirakata; Distinction of Cone Outer Segment Tips and Foveal Disruption Artifacts in Spectral-Domain Optical Coherence Tomography Images of Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2880.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To investigate the incidence and possible causes of obscured or disrupted cone outer segment tips (COST) line at fovea in spectral-domain optical coherence tomography (SD-OCT) images of normal eyes.

 
Methods:
 

Seventy eyes of 35 individuals without eye diseases were included in this study. OCT images were taken using Cirrus HD-OCT (Carl Zeiss Meditec) with 5 line raster (5LR) and high-definition 5 line raster (HD5LR) modes. Images with signal strength (S/S) weaker than 6/10 were excluded. Distinction of COST lines was graded to A (distinct), B (discernible), or C (obscured). The integrity of COST line, external limiting membrane (ELM), and the photoreceptor inner segment and outer segment (IS/OS) junction at the fovea were recorded. Demographic data, refractive error of the eyes, signal strengths of the OCT images were acquired for analysis.

 
Results:
 

The distinction grades of COST line were grade A: 45%, grade B: 34%, grade C: 21% in 5LR mode; grade A: 81%, grade B: 11%, grade C: 8% in HD5LR mode. COST distinction grade was correlated to the COST distinction status of the fellow eye (r = 0.62). COST distinction grade and COST disruption were not significantly correlated to age, sex, refractive error of the eyes, or the S/S of the OCT images. The incidence of COST line disruption at fovea was 12.4% in 5LR mode; 10.3% in HD5LR mode. COST line disruption was always associated with ELM and IS/OS disruption. Hyper-reflectivity at the foveal pit surface was noted in 44% of the eyes with disrupted COST line in 5LR mode and in 87% of the eyes with disrupted COST line in HD5LR mode.

 
Conclusions:
 

COST line distinction varies and disrupted COST lines are noted in approximate 10% of SD-OCT images of normal eyes. COST line disruption in eyes with normal visual function was associated with ELM and IS-OS disruption. The artifact is presumably due to the surface hyper-reflectivity at the foveal pit.  

 
Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
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