Purchase this article with an account.
Gustavo Sanchez-Bermudez, Sr., Igal M. Zand-Hadas, Andree Henaine-Berra, Gerardo Garcia-Aguirre, Juan Jimenez-Sierra; Analysis Of Spectral Domain Oct Characteristics In Patients With Rod Monochromatism. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2882.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate structural changes by spectral domain optical coherence tomography (OCT) by observation of the central retinal architecture in patients with rod monochromatism (achromatopsia) in Mexican individuals.
This is a descripitive, transversal study. Eight patients with rod monochromatism were included; the diagnosis of achromatopsia was established by means of visual acuity, standard electroretinogram, and color vision tests. SD-OCT was performed in all patients with the Spectralis OCT (Heidelberg Engineering). The examination included a central linear 100-frame scan and 25° x 25° 30-frame volume cube. Images were analyzed by direct observation of the foveal architecture, RPE, and Inner-Outer segment junction of central photoreceptors. Measurement of foveal thickness was also performed with auto segmentation. OCT findings were correlated with best corrected visual acuity and electrophysiological studies.
Eight patients (Sixteen eyes) with diagnosis of rod monochromatism (complete and incomplete) were evaluated, 5 males (62.5%) and 3 females (37.5%). The mean age was 20.6 years (4 - 42 ), the average BCVA was 20/100, the mean central thickness was 186.3 ± 28.5 µm ; the foveal depression was normal in all patients; absence of the IS/OS junction was observed in the foveal region in both eyes on 4 patients (50%), which did not correlated with BCVA. None of the patients had epiretinal membrane, cystoid macular edema or retinal pigment epithelium abnormalities.
In this study 8 eyes showed changes in the foveal architecture. Advanced Imaging techniques such as the SD-OCT are helpful for the structural analysis of the retinal architecture in a wide spectrum of retinal diseases including the congenital retinal disorders. In this study we did not find a consistent structural anomaly in patients with the same diagnosis. A larger population of patients should be evaluated and compared with a control group.
This PDF is available to Subscribers Only