April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Systolic-Diastolic Variation of Retinal Vessels Diameter in Diabetic Patients without Diabetic Retinopathy Detected by the Retinal Vessel Analyzer
Author Affiliations & Notes
  • Katarzyna Makowiecka
    Department of Functional Investigations of Vision,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Amelie Lecleire-Collet
    Department of Ophthalmology,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Jean-Francois Le Gargasson
    Department of Functional Investigations of Vision,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Philippe Bonnin
    Department of Functional Investigations of Vision,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Alain Gaudric
    Department of Ophthalmology,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Pascale Massin
    Department of Ophthalmology,
    AP-HP Lariboisiere Hospial, University Paris 7 Denis Diderot, Paris, France
  • Footnotes
    Commercial Relationships  Katarzyna Makowiecka, None; Amelie Lecleire-Collet, None; Jean-Francois Le Gargasson, None; Philippe Bonnin, None; Alain Gaudric, None; Pascale Massin, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2886. doi:
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      Katarzyna Makowiecka, Amelie Lecleire-Collet, Jean-Francois Le Gargasson, Philippe Bonnin, Alain Gaudric, Pascale Massin; The Systolic-Diastolic Variation of Retinal Vessels Diameter in Diabetic Patients without Diabetic Retinopathy Detected by the Retinal Vessel Analyzer. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2886.

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Abstract

Purpose: : The purpose of this study was to assess the systolic-diastolic (S-D) variation of retinal vessels diameter in diabetic patients without diabetic retinopathy (DR).

Methods: : Twenty-three patients with diabetes (9 with type 1 and 14 with type 2) without DR and twenty-six healthy subjects (control) were examined with the Retinal Vessel Analyzer. The mean age of the groups was matched.

Results: : There were significant differences between (S-D) diameter variation of the arteries (1,9±1,0 vs 3,0±1,0 µm; p< 0,05) and of the veins (1,8 ± 0,92 vs 2,87 ± 1,2 µm; p< 0,05) in diabetic patients compared to the control group. There was no significant difference between mean diameter of retinal arteries and veins respectively in both groups (118 ± 17 vs 114 ± 11; 152 ± 20 vs 143 ± 19 µm).

Conclusions: : The significant decrease of the (S-D) variation of retinal vessels diameter in diabetic patients compared to normal subjects suggests an alteration in the structure and mechanical properties of the retinal vessel which are present before clinical signs of diabetic retinopathy appear. The Retinal Vessel Analyzer is a unique and non-invasive method to detect very early retinal vessels dysfunctions in diabetes.

Keywords: diabetic retinopathy • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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