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Katarzyna Makowiecka, Amelie Lecleire-Collet, Jean-Francois Le Gargasson, Philippe Bonnin, Alain Gaudric, Pascale Massin; The Systolic-Diastolic Variation of Retinal Vessels Diameter in Diabetic Patients without Diabetic Retinopathy Detected by the Retinal Vessel Analyzer. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2886.
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The purpose of this study was to assess the systolic-diastolic (S-D) variation of retinal vessels diameter in diabetic patients without diabetic retinopathy (DR).
Twenty-three patients with diabetes (9 with type 1 and 14 with type 2) without DR and twenty-six healthy subjects (control) were examined with the Retinal Vessel Analyzer. The mean age of the groups was matched.
There were significant differences between (S-D) diameter variation of the arteries (1,9±1,0 vs 3,0±1,0 µm; p< 0,05) and of the veins (1,8 ± 0,92 vs 2,87 ± 1,2 µm; p< 0,05) in diabetic patients compared to the control group. There was no significant difference between mean diameter of retinal arteries and veins respectively in both groups (118 ± 17 vs 114 ± 11; 152 ± 20 vs 143 ± 19 µm).
The significant decrease of the (S-D) variation of retinal vessels diameter in diabetic patients compared to normal subjects suggests an alteration in the structure and mechanical properties of the retinal vessel which are present before clinical signs of diabetic retinopathy appear. The Retinal Vessel Analyzer is a unique and non-invasive method to detect very early retinal vessels dysfunctions in diabetes.
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