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Sami S. Rezeq, Kapil M. Sampat, Jay Chhablani, Sunir J. Garg, William R. Freeman, Julia A. Haller, Andre J. Witkin, Dirk-Uwe G. Bartsch; Comparative Analysis of the Macula in Normal and Pathologic Eyes Using The Retinal Function Imager (RFI), a Novel, Non-Invasive Imaging Technique. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2899.
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© ARVO (1962-2015); The Authors (2016-present)
To identify and compare capillary networks in normal eyes and in eyes with retinovascular diseases using the Retinal Function Imager (RFI) and fluorescein angiography (FA).
The RFI acquires a rapid sequence of stroboscopic retinal images using green light (548nm) at a high frequency (50-100hz). This sequence of images can be averaged to create a signal-enhanced capillary map without the use of dye based on movement of red blood cells. A total of 10 normal eyes and 10 eyes with retinovascular diseases were imaged with the RFI and FA at the same visit. Vascular characteristics within the macula, and the total size of areas of non-perfusion, were analyzed and compared between corresponding FA and RFI images of the same eye with the same field angle.
There was a high concordance between FA and RFI capillary maps in the 10 normal eyes. In patients with retinal vascular disease, the RFI over-indentified areas of nonperfusion compared with FA. RFI was uniquely able to visualize vessels that crossed the horizontal raphe in 9/10 normal eyes, while this was not visualized on FA. In retinal vascular diseases, RFI captured a mean of 4 anastamotic vessels per image, while FA captured a mean of 3.
The RFI is capable of obtaining highly detailed capillary perfusion maps without the use of intravenous dye. RFI accurately identifies areas of non-perfusion and reveals collateral blood flow in as much, or often greater, detail than FA. However, unlike FA, the RFI does not identify areas of leakage.
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