April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Optical Coherence Tomography and Visual Outcomes Of Anti-VEGF Therapy For Exudative Age-related Macular Degeneration (ARMD) In The Presence Of Epiretinal Membrane - A Pilot Study
Author Affiliations & Notes
  • Baseer Ahmad
    Ophthalmology, Cleveland Clinic, Cleveland, Ohio
  • Rishi Singh
    Ophthalmology, Cleveland Clinic, Cleveland, Ohio
  • Footnotes
    Commercial Relationships  Baseer Ahmad, None; Rishi Singh, Alcon (C), Genentech (C), Inspire Pharmaceuticals (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2901. doi:
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      Baseer Ahmad, Rishi Singh; Optical Coherence Tomography and Visual Outcomes Of Anti-VEGF Therapy For Exudative Age-related Macular Degeneration (ARMD) In The Presence Of Epiretinal Membrane - A Pilot Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2901.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine whether the presence of epiretinal membranes in the setting of exudative ARMD are associated with less favorable reduction in retinal thickness (as measured by OCT) and visual outcomes after treatment with anti-VEGF agents.

Methods: : A retrospective chart review was conducted of exudative ARMD patients being treated with periodic ranibizumab injections. Epiretinal membrane presence was established by Carl Zeiss Cirrus HD-OCT imaging of the macula. Seven eyes were found in the epiretinal membrane group, while fifteen were included in the control group. Data collected included visual outcomes and OCT center subfield thickness at initial date of diagnosis, 1 month, 3 months, and 6 months.

Results: : Of 7 eyes with OCT-proven ERMs at presentation of new exudative ARMD, visual acuity improved >1 line in 2 eyes, stayed within 1 line in 2 eyes, and decreased >1 line in 3 eyes. Initial median visual acuity was 20/40, and stayed at 20/40 at 6 months. OCT measurement of retinal thickness showed decrease of >20 microns in 3 eyes, 20 microns in 1 eye. (The seventh eye did not have initial OCT data). Initial average retinal thickness was 309 micron and 263 at 6 months. Of 11 eyes without ERM at presentation, visual acuity improved in 4 eyes, stayed within 1 line line in 7 eyes, and decreased in 1 eye. Initial median visual acuity was 20/50, and was 20/40 at 6 months. OCT measurement of retinal thickness showed decrease >20 micron change in 8 eyes, <20 micron change in 3 eyes, and no increase in any eyes. Initial average retinal thickness was 356 micron and 243 at 6 months.

Conclusions: : In eyes with exudative ARMD treated with ranibizumab, the presence of an epiretinal membranes may be a negative prognostic indicator in terms of vision and retinal thickness reduction as measured by OCT. A larger study, preferably prospective, would be needed to validate this suggestion.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual acuity • age-related macular degeneration 
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