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Cristina Pujadas Garcia, MA Zapata Victori, Carme Macià Badia, Jose Garcia-Arumi; Correlation Between The Qualitative And Quantitative State Of The Inner-outer Segment Of The Photoreceptors And The Visual Acuity In Patients With Closed Macular Hole After Surgery. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2904.
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To evaluate the correlation between the qualitative and quantitative state of the inner-outer segment of the photoreceptors and the long term visual acuity in patients with closed macular hole after surgery.
We studied 22 eyes of 19 patients with surgically closed macular hole with more than a year of follow up. In all patients we performed best corrected visual acuity (Snellen) and a spectral-domain optic coherence last generation tomography (CIRRUS®), 5HD line raster and 512x128 Cube. Qualitative state was considered as normal-altered-absent. Quantitative defect was performed manually by two ophthalmologists; a third reader was used when discrepancy was higher than 10%. We analyze also the demographic characteristics (age and sex) and their influence in the anatomic and functional results. SPSS v15 was used for statistical analysis, using specific non parametric test (U-Mann Whitney test, Kruskal Wallis test and Rho Spearman correlation).
We found statistically significant differences between visual acuity and the qualitaty pattern of the IS/OS in the OCT (p = 0,002). Normal BVAC logMar 0,16 vs Altered + pathologic group BVAC logMar 0,6625 (p=0,02), normal + altered BVAC logMar 0,31 vs pathological group BVAC logMar 1,0375 (p=0,04). The quantitative defect was 329,432 µm ± 394,44 in the raster high definition protocol and 387,61 µm ± 452,19 in the Cube protocol. Visual acuity was better in patients with smaller defects of the IS/OS (p < 0,001 in CUBE 512 X128 and p < 0,001 in 5 HD RASTER). There were no difference between age and sex and the characteristic of the IS/OS, we didn’t find also differences between age and sex and the visual acuity.
Long term visual acuity after surgically closure of the macular hole is related to the qualitative and quantitative characteristics of the IS/OS. These characteristics could explain the variability of the final visual acuity in these patients. The relevance of the IS/OS segment in the prognostic of the macular hole before the surgery should be studied.
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