April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Mapping Of Optical Coherence Tomography (OCT) - Pathologies And Correlation To Best Corrected Visual Acuity (BCVA) - Results In Subvoveal CNV - Patients
Author Affiliations & Notes
  • Philipp K. Roberts
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Christopher Kiss
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Marion Munk
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Magdalena Barasits
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Christian Simader
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Alessio Montuoro
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Philipp K. Roberts, None; Christopher Kiss, None; Marion Munk, None; Magdalena Barasits, None; Christian Simader, None; Alessio Montuoro, None; Ursula Schmidt-Erfurth, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2906. doi:
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      Philipp K. Roberts, Christopher Kiss, Marion Munk, Magdalena Barasits, Christian Simader, Alessio Montuoro, Ursula Schmidt-Erfurth; Mapping Of Optical Coherence Tomography (OCT) - Pathologies And Correlation To Best Corrected Visual Acuity (BCVA) - Results In Subvoveal CNV - Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2906.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To measure areas of different pathologies in the different layers of the retina in untreated subfoveal CNV-patients and find possible correlations to the BCVA-results. Detection of VA-relevant changes in Spectral Domain (SD)- OCT caused by treatment-naïve subfoveal CNV.

Methods: : A total of 35 eyes of 35 patients with treatment-naïve CNV were included. BCVA at baseline, measured in total letters was compared to the findings in SD-OCT-images (Spectralis® by Heidelberg engineering). Each cross-sectional image of a defined data set was graded for following pathologies: External limiting membrane (ELM) disrupted, inner segment - outer segment boundary (IS/OS) disrupted, subretinal fluid (SRF) present, Pigment Epithelium Detachment (PED) present, drusen present. Within the OCT-toolkit v1.5 program, it is possible to manually segment areas on each cross sectional image scan (B-scan). The program calculates the total area of each pathology (in mm²), which is then displayed on the en-face fundus-image.

Results: : Disrupted ELM area correlated significantly (R = 0,361, p = 0,033) with BCVA. However, the areas investigated for the other pathological findings (IS/OS disrupted, presence of SRF, PED and drusen) did not significantly correlate with the BCVA-results. The integrity of the ELM itself correlated significantly with the intactness of the IS/OS (R = 0,641 , p = 0,000), the presence of SRF(R = 0,621 , p = 0,000) and drusen (R = 0,500, p = 0,002).

Conclusions: : The integrity of the ELM seems to be an important marker for visual function in subfoveal CNV-patients. Further studies have to be conducted to confirm these results.

Keywords: visual acuity • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: non-clinical 
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