March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Use Of A Novel Software In Predicting Progression Of Diabetic Retinopathy Through Measurement Of Retinal Vascular Changes
Zuzana Sipkova; Anthia Papazoglou; David Sculfor; Consuela Moorman; Larry Benjamin; Peter Bankhead; Graham McGeown; Timothy Curtis; Victor Chong
Author Affiliations & Notes
  • Zuzana Sipkova
    Oxford Eye Hospital, University of Oxford, Oxford, United Kingdom
  • Anthia Papazoglou
    Oxford Eye Hospital, University of Oxford, Oxford, United Kingdom
  • David Sculfor
    Department of Ophthalmology, Stoke Mandeville Hospital, Aylesbury, United Kingdom
  • Consuela Moorman
    Department of Ophthalmology, Stoke Mandeville Hospital, Aylesbury, United Kingdom
  • Larry Benjamin
    Department of Ophthalmology, Stoke Mandeville Hospital, Aylesbury, United Kingdom
  • Peter Bankhead
    Centre for Vision and Vascular Sciences, Queen’s University of Belfast, Belfast, United Kingdom
  • Graham McGeown
    Centre for Vision and Vascular Sciences, Queen’s University of Belfast, Belfast, United Kingdom
  • Timothy Curtis
    Centre for Vision and Vascular Sciences, Queen’s University of Belfast, Belfast, United Kingdom
  • Victor Chong
    Oxford Eye Hospital, University of Oxford, Oxford, United Kingdom
  • Footnotes
    Commercial Relationships  Zuzana Sipkova, None; Anthia Papazoglou, None; David Sculfor, None; Consuela Moorman, None; Larry Benjamin, None; Peter Bankhead, None; Graham McGeown, None; Timothy Curtis, None; Victor Chong, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2844. doi:
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      Zuzana Sipkova, Anthia Papazoglou, David Sculfor, Consuela Moorman, Larry Benjamin, Peter Bankhead, Graham McGeown, Timothy Curtis, Victor Chong; The Use Of A Novel Software In Predicting Progression Of Diabetic Retinopathy Through Measurement Of Retinal Vascular Changes. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2844.

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Abstract

Purpose: : To evaluate a new software in measuring retinal vascular changes in patients with diabetes as a risk factor for progression.

Methods: : The database of a hospital-based diabetic retinopathy screening was assessed retrospectively. 408 patients were identified to have over 6 years of follow up between 2004 and 2011. Patients with retinopathy on baseline were excluded from the study. Non-Progression group (NPG) is defined as no retinopathy on baseline or at last follow up, whilst Progression group (PG) had no retinopathy on baseline but retinopathy present at last follow up. We have used only the right eye of each patient for analysis. In this preliminary study, we have selected a random sample of 35 images from each group. The central retinal arteriolar (CRAE) and venular equivalence (CRVE) on baseline images were measured using a new software. Using this software, the CRAE and CRVE can be calculated in patients with only the temporal part of the optic disc included in the image. Two observers (ZS and AP) have carried out the measurement independently. Student t-test was used for statistical analysis.

Results: : The inter-observer differences were not statistically significant. The mean measurement was used for analysis. Out of the 70 patients, 14 (7 from each group) were excluded due to poor image quality. The mean CRAE unit in the NPG and PG were 14.27 (SD 1.67) and 14.88 (SD 1.36), respectively, and the mean CRVE unit in the NPG and PG were 17.85 (SD 1.67) and 18.90 (SD 1.98). The progression group has significantly wider CRVE (p=0.018) but not CRAE (p=0.068) than the non-progression group. The A-V ratio did not show a significant difference (p=0.31).

Conclusions: : This new software appears to be able to measure retinal vascular changes reliably. We were able to confirm even with this small sample size that dilation of retinal vein is a risk factor of diabetic retinopathy progression. The full dataset analysis is currently under evaluation.

Keywords: diabetic retinopathy • diabetes 
© 2012, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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