March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Longitudinal Changes In Retinal Nerve Fiber Layer Thickness After Panretinal Photocoagulation In Diabetic Retinopathy
Author Affiliations & Notes
  • Jung Yeul Kim
    Ophthalmology, Chungnam Natl Univ Hosp, Daejeon, Republic of Korea
  • Kyung sup Shin
    Ophthalmology, Chungnam Natl Univ Hosp, Daejeon, Republic of Korea
  • Kiyup Nam
    Ophthalmology, Chungnam Natl Univ Hosp, Daejeon, Republic of Korea
  • Footnotes
    Commercial Relationships  Jung Yeul Kim, None; Kyung sup Shin, None; Kiyup Nam, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2854. doi:
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    • Get Citation

      Jung Yeul Kim, Kyung sup Shin, Kiyup Nam; Longitudinal Changes In Retinal Nerve Fiber Layer Thickness After Panretinal Photocoagulation In Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2854.

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Abstract

Purpose: : To investigate longitudinal changes in retinal nerve fiber layer (RNFL) thickness after panretinal photocoagulation (PRP) in diabetic retinopathy patients.

Methods: : This prospective study examined 31 eyes in 25 patients undergoing PRP, who were diagnosed with severe nonproliferative diabetic retinopathy or non-high-risk proliferative diabetic retinopathy. Optical coherence tomography was conducted before PRP and at 3, 6, 12, and 24 months following PRP to investigate changes in RNFL thickness.

Results: : Superior, nasal, inferior, temporal, and mean RNFL thicknesses increased until 6 months after PRP, and then decreased. Superior RNFL thickness increased significantly at 3 and 6 months, and decreased significantly at 24 months compared with the baseline RNFL thickness. Nasal RNFL thickness declined significantly at 24 months compared with the baseline RNFL thickness without any significant increase in thickness during the follow-up period. Inferior RNFL thickness increased significantly at 6 months and decreased significantly at 24 months compared with its baseline RNFL thickness. Temporal thickness increased significantly at 3, 6, 12, and 24 months compared with the baseline RNFL thickness. Mean RNFL thickness increased significantly at 6 months and decreased significantly at 24 months. Central subfield thickness increased significantly at 3, 6, 12, and 24 months compared with its baseline thickness.

Conclusions: : RNFL thickness increased at 6 months after PRP, and then decreased at 24 months following PRP compared with baseline RNFL thickness in diabetic retinopathy patients. This finding suggests that in addition to diabetes itself, diabetic retinopathy, and associated glaucoma, PRP may be a cause of RNFL thickness loss in diabetes patients.

Keywords: nerve fiber layer • diabetic retinopathy • laser 
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