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Oren Z. Plous, Diabetic Retinopathy Clinical Research Network; Retinal Thickness and Volume Reproducibility Comparison using Zeiss Stratus Time Domain and Heidelberg Spectralis Spectral Domain OCT in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2865.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate reproducibility of central subfield retinal thickness and volume measurements from optical coherence tomography (OCT) images that were obtained by time domain Zeiss Stratus OCT and spectral domain Heidelberg Spectralis OCT in participants with diabetic macular edema (DME).
Participants enrolled in this prospective observational study had at least one eye with center involved DME (Stratus OCT central subfield thickness ≥250 μm). Certified OCT operators at DRCR.net sites obtained OCT scans according to standard procedures. Pupils were dilated for 30 minutes to at least 5 mm before initial scan. For each machine, the right eye was scanned first. Each study eye received two replicate scans by Stratus (fast macular map protocol) followed by two replicate scans by Spectralis (20 x 20, 49 Bscans, high resolution, ART of 15). All measurements in this analysis were taken directly from the instrument software.
Five Hundred fifty four eyes of 293 participants (mean age 63±11 years, 43% women) were enrolled in the study. The mean ± standard deviation central subfield thickness was 307 ± 104 and 368 ± 105 on the first scan performed with Stratus and Spectralis, respectively. Median absolute difference between the measurement from the first and second scan in each eye for Stratus central subfield thickness and retinal volume were 7 µm and 0.07 mm3, respectively; whereas for Spectralis these values were 2 µm and 0.03 mm3.
Reproducibility data for central subfield thickness and retinal volume measurements for Zeiss Stratus and Heidelberg Spectralis were evaluated over a broad range of central retinal thickness in participants withdiabetes and at least one eye with DME. Reproducibility of these measures on Spectralis appears at least as good as Stratus, within this cohort of participants at DRCR.net clinical sites.
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