March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Drusen Area versus Retinal Pigment Epithelium-Drusen Complex Volume in Intermediate Age-related Macular Degeneration
Author Affiliations & Notes
  • Stefanie Schuman
    Ophthalmology, Duke Eye Center, Durham, North Carolina
  • Rachelle O'Connell
    Ophthalmology, Duke Eye Center, Durham, North Carolina
  • Sina Farsiu
    Ophthal & Biomed Engineering,
    Duke University, Durham, North Carolina
  • Stephanie J. Chiu
    Biomedical Engineering,
    Duke University, Durham, North Carolina
  • G B. Hubbard, III
    Ophthalmology, Emory Univ Eye Center, Atlanta, Georgia
  • Wai T. Wong
    Unit on Neuron-Glia Interactions, National Eye Institute, Bethesda, Maryland
  • Thomas S. Hwang
    Ophthalmology, Casey Eye Institute CEI-4, Portland, Oregon
  • Sunil K. Srivastava
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
  • Emily Y. Chew
    Epidemiology & Clinical Applications, National Eye Inst/NIH, Bethesda, Maryland
  • Cynthia A. Toth
    Ophthalmology, Duke Univ Eye Center, Durham, North Carolina
  • Footnotes
    Commercial Relationships  Stefanie Schuman, None; Rachelle O'Connell, None; Sina Farsiu, unlicensed (P); Stephanie J. Chiu, unlicensed (P); G. B. Hubbard, III, None; Wai T. Wong, None; Thomas S. Hwang, None; Sunil K. Srivastava, None; Emily Y. Chew, None; Cynthia A. Toth, Alcon, Bioptigen, unlicensed (P), Bioptigen, Genentech (F), Physical Sciences Incorporated (C)
  • Footnotes
    Support  Genentech grant (IST-4400S), Bioptigen (equipment), and Alcon Laboratories (unrestricted startup grant), John Chambers Fellowship (S.J.C.), NIH P30 EY-005722 (S.F.)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2909. doi:
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      Stefanie Schuman, Rachelle O'Connell, Sina Farsiu, Stephanie J. Chiu, G B. Hubbard, III, Wai T. Wong, Thomas S. Hwang, Sunil K. Srivastava, Emily Y. Chew, Cynthia A. Toth; Drusen Area versus Retinal Pigment Epithelium-Drusen Complex Volume in Intermediate Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2909.

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      © ARVO (1962-2015); The Authors (2016-present)

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To evaluate the relationship between RPE-drusen complex (RPEDC) volumes from spectral domain optical coherence tomograms and measurement of drusen area from color fundus photographs (CFP), in the baseline eyes of the prospective randomized Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study (A2A SDOCT Study, NCT00734487).


Three-dimensional SDOCT images were automatically segmented using validated DOCTRAP software on 314 eyes with intermediate age-related macular degeneration (AMD) and 122 control eyes from the prospective A2A SDOCT study. Certified SDOCT analysts reviewed segmentation for accuracy and corrected gross errors. Total RPE-drusen complex volume (RPEDC) volume was computed within 1-mm and 5-mm rings centered on the fovea. CFP were graded by the Wisconsin Reading Center, scoring for drusen area within the Center Subfield (1-mm dia.) and within the Grid (6-mm dia.).


Quantitative assessment was performed on 256 of 314 AMD eyes and 118 of 122 control eyes. Mean (SD) total RPEDC volume was 0.686 (0.213) mm3 in AMD eyes, and 0.550 (0.07) mm3 in control eyes (P<0.001, unpaired t-test). Review of paired CFP images and SDOCT RPEDC volume maps showed regional variations in thickness, such as from geographic atrophy that explained some of the variance in RPEDC volume. Median total RPEDC volumes for both 1- and 5-mm diameter (Fig. 1) were significantly different when binned by CFP score (P=0.0001, Kruskal-Wallis). RPEDC volume and CFP drusen area score were correlated (Spearman’s Rho = 0.54 and 0.50, respectively, P<0.0001).


The RPE-drusen complex volume derived from SDOCT images may be a clinically useful tool for distinguishing and assessing AMD. While comparable to drusen area on CFP, this unique measure may enable further risk stratification. Longitudinal study will assess the predictive value of SDOCT-based RPEDC volume in AMD progression.  

Clinical Trial: NCT00734487

Keywords: age-related macular degeneration • imaging/image analysis: clinical 

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