March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Predictive Factors of Visual Acuity Deterioration after Ranibizumab Treatment for Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Author Affiliations & Notes
  • Yuji Oshima
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Miho Yasuda
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Kumiko Kano
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Ayako Yoshida
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Hitomi Asato
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Shintaro Nakao
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Shigeo Yoshida
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Tatsuro Ishibashi
    Ophthalmology, Kyushu Univ, Faculty of Med, Fukuoka, Japan
  • Footnotes
    Commercial Relationships  Yuji Oshima, None; Miho Yasuda, None; Kumiko Kano, None; Ayako Yoshida, None; Hitomi Asato, None; Shintaro Nakao, None; Shigeo Yoshida, None; Tatsuro Ishibashi, None
  • Footnotes
    Support  Grant-in-Aid for Scientific Research, Japan (C 23592573)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2917. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yuji Oshima, Miho Yasuda, Kumiko Kano, Ayako Yoshida, Hitomi Asato, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi; Predictive Factors of Visual Acuity Deterioration after Ranibizumab Treatment for Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2917.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To investigate the predictive factors of visual acuity deterioration one year after intravitreal injections of ranibizumab (IVR) for age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) in Japanese patients.

Methods: : One hundred fifty two eyes undergoing IVR treatment (AMD 84 eyes; PCV 68 eyes) were retrospectively studied. Best-corrected visual acuity (BCVA) change of 0.3 or more in log MAR VA was considered significant. Worsening in BCVA was defined as a decrease of > 0.3 log MAR units. The BCVA outcomes at one year after treatment were analyzed based on the following: age, sex, VA, greatest linear dimension, past treatment, FA classification, central retinal thickness, retinal bleeding, retinal pigment epithelium detachment (PED), hypertension, diabetes, and smoking habits.

Results: : Log MAR VA decreased by 0.3 or more in 21 eyes (13.8%) (AMD 12 eyes; PCV 9 eyes). Multivariate logistic regression analysis found the independent predictor for VA deterioration to be serous PED (odds ratio [OR], 3.93; 95% confidence interval [CI], 1.35 to 14.3) and the absence of classic choroidal neovascularization (CNV) (OR, 4.25; 95%CI, 1.65 to 10.8).

Conclusions: : IVR is well tolerated in eyes of Japanese patients with AMD and PCV. PED and the absence of classic CNV at baseline may be risk factors for VA deterioration.

Keywords: choroid: neovascularization • age-related macular degeneration • vascular endothelial growth factor 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×