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Swati Tomar, Pradeep Mathur; Anti Oxidant Therapy In Age Related Macular Degeneration: A Change In Oxidant Enzyme Status, Lipid Peroxidation And Oxidative Stress -A Hope For Vision. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2937.
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Oxidative stress is implicated in Age Related Macular Degeneration. Radicals of superoxide anion and reactive non- radical oxygen species (hydrogen peroxide) cause oxidative stress. The study aimed to determine the anti oxidant status of patients with Dry ARMD and the role of oral antioxidant therapy
Study was conducted on 100 eyes of 50 patients above 50 years of age with dry ARMD.Patients were divided into three groups.Estimation of enzymes Superoxide dismutase and Malanodialdehyde was done in serum.Group:1 This group served as control consisting of 24 patients who did not receive any antioxidant therapy.Group:2 This group constituted 13 patients who received oral tablet carofit each containing carrot extract (carotenoids and Micro-nutrients) 100 mg ,beta carotene 7.5% dispersion (nature carotenoids) 40mg.Patients received 1 tablet twice a day for six weeks.Group:3This group constituted 13 patients received oral tablet ocugold each containing natural carotenoid rich in lutein /zeaxanthin-3.2 mg (containing not less then 3mg of lutein/zeaxanthin) beta -carotene 1.2 mg, carrot extract (carotenoids and micronutrients 100mg).Patient received 1 tablet twice a day for three months
Superoxide dismutase enzyme levels:Group-1 The mean base line superoxide dismutase enzyme level at first visit in group 1 was 400.75 unit/ml of serum which decreased to 372.07 units/ml on follow up after 6 weeks (p value 0.007).Group:-2 The mean pretreatment SOD levels in group 2 (carofit treated group) was 323.58 unit/ml which increased to 495.1 unit/ml in post treatment follow up after 6 weeks (p value<0.01).Group:-3 The mean pre treatment SOD levels in group 3(ocugold treated) was 333.96 unit/ml of serum which increased to 398.67 unit/ml in the post treatment follow up after 6 weeks (p value<0.01). Malanodialdehyde enzyme levels:Group -1:The mean base line MDA enzyme level at first visit in group 1 was 2.84 nmols/ml of serum which slightly decreases to2.46 nmols/ml on follow up after 6 weeks (p value 2.14).Group:-2 The mean pretreatment MDA levels was 2.65 nmols/ml which decreased to 2.4nmols/ml on post treatment follow up after 6 weeks (p value<0.1).Group:-3 The mean pre treatment MDA levels was 3.05 nmols/ml which significantly decreased to 1.92 nmols/ml in the post treatment follow up after 6 weeks (p value<0.01)
Our observations strongly suggest and support the role of antioxidant treatment in patients with dry ARMD which could well be a future marker for preventing wet ARMD which is the blinding spectrum of the disease
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