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Stephan Michels, Stephan L. Kaminski, Rike Michels; Effect of Combined Topical Heparin and Steroid on Corneal Neovascularization in Children. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2955.
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To demonstrate the effect of topical heparin combined with topical steroid on corneal neovascularizations (CN) in children.
Four children (5 eyes) with new onset progressive CN in at least one eye received topical rimexolone or dexamethasone in combination with heparin until complete regression of the CN is obtained. The regression of CN is documented by slit-lamp/anterior segment photography.
All 5 eyes showed complete regression of the CN within 5 months. An anti-angiogenic effect was found as early as one week following start of topical combination treatment. No ocular and systemic side effects were detected and treatment was well tolerated by all children. In the 3 eyes with involvement of the optical axis symmetrical visual acuity was obtained by amblyopia treatment. Recurrence of the CN was detectable in 2 eyes at one and six months after ending combination therapy. Both eyes responded favourably to retreatment.
Combination of topical heparin and steroid leads to rapid regression and complete inactivity of CN. This therapeutic approach is promising especially in children with limited therapeutic alternatives and a high risk for amblyopia.
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