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Kayoko Ueda, Akira Ohtori, Kakuji Tojo; Ocular Pharmacokinetics For Aphakic Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3233. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Due to the difference in anatomical characteristics, the ocular pharmacokinetics may be influenced by the absence of the lens tissue in the aphakic eyes. From the mathematical simulation model for ocular pharmacokinetics, the effect of the lens tissues in the eyes was compared with that in the normal eyes.
The mathematical model for ocular pharmacokinetics has been developed on the basis of diffusion and partition model. The aphakic eye was simulated by removing the lens tissue from the general ocular pharmacokinetic model. The model parameters were then determined by independent experiments in vivo and in vitro, and from the literatures. The distribution of the drug molecules in the eye tissues for either normal eyes or aphakic eyes after cataract surgery was theoretically simulated and compared with the in vivo data reported in the literature.
The mathematical model for ocular pharmacokinetics well described the concentration distribution in the eye for aphakic eyes as well as that in the normal eyes. In normal eyes, the reservoir function of the lens was found at around 30 hours after eye drop instillation. On the other hand, the aphakic eyes clearly showed that the reservoir function substantially disappeared after topical instillation. It is also surprising that the concentration distribution profile in the aqueous humor and vitreous humor was hardly influenced by the absence of the lens tissue. In the normal lens, the concentration was significantly prolonged by the reservoir function of the lens tissues.
The present diffusion-partition model could analyze the pharmacokinetics of ocular drugs after cataract surgery as well as the normal eyes. The model could also confirm the distribution and the elimination in the eye according to the pathological conditions. The cataract surgery may shorten markedly the elimination of drugs in the eye.
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