April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Drug Penetration to the Posterior Vitreous Body after Topical Instillation
Author Affiliations & Notes
  • Yuko Shikamura
    Senju Pharmaceutical Co., Ltd., Kobe, Japan
    Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
  • Akira Ohtori
    Senju Pharmaceutical Co., Ltd., Kobe, Japan
    Laboratory of Ocular Drug Delivery System, Kyushu Institute of Technology, Fukuoka, Japan
  • Kakuji Tojo
    Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
    Laboratory of Ocular Drug Delivery System, Kyushu Institute of Technology, Fukuoka, Japan
  • Footnotes
    Commercial Relationships  Yuko Shikamura, None; Akira Ohtori, None; Kakuji Tojo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3242. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yuko Shikamura, Akira Ohtori, Kakuji Tojo; Drug Penetration to the Posterior Vitreous Body after Topical Instillation. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3242.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : In our previous in vivo rabbit pharmacokinetic studies, the drug concentration at the posterior vitreous body initially decreased with time after topical instillation, and thereafter the concentration increased. The purpose of this study is to analyze this interesting time course of vitreous body concentration by the mathematical simulation model on the basis of the diffusion model.

Methods: : The ocular pharmacokinetic model developed is based on the Fick’s law of diffusion and a modified cylindrical model. The model parameters, the diffusion coefficient in various ocular tissues, are independently determined from in vitro experiment. The concentration distribution of ofloxacin in the eye was calculated after solving the governing partial differential equation. The calculated profiles were then compared with the in vivo experimental profiles.

Results: : In silico simulation for ocular pharmacokinetics indicated that the drug penetration to the posterior vitreous body was determined by three major pathways after topical instillation: (1) initial transscleral penetration, (2) middle transcorneal penetration and (3) late transretinal penetration. The in vivo penetration profile in the posterior vitreous body was clearly described by a series of contribution of these three pathways.

Conclusions: : The present in silico study suggests that the instilled drugs reach the posterior vitreous body via the conjunctiva/sclera and slowly via the cornea penetration and systemic circulation. The theoretically simulated profile was very consistent with the in vivo rabbit experiments.

Keywords: vitreous 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×