April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Photodynamic Therapy For The Treatment Of Amelanotic Choroidal Melanoma
Author Affiliations & Notes
  • Sahitya V. Reddy
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Kiran Turaka
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Rishav D. Kansal
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Zunair A. Mahmood
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Carlos Bianciotto
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Carol L. Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Sahitya V. Reddy, None; Kiran Turaka, None; Rishav D. Kansal, None; Zunair A. Mahmood, None; Carlos Bianciotto, None; Carol L. Shields, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3278. doi:
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      Sahitya V. Reddy, Kiran Turaka, Rishav D. Kansal, Zunair A. Mahmood, Carlos Bianciotto, Carol L. Shields; Photodynamic Therapy For The Treatment Of Amelanotic Choroidal Melanoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3278.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the efficacy and safety of photodynamic therapy (PDT) for treatment of amelanotic choroidal melanomas.

Methods: : Retrospective review of medical records. The participants were five consecutive patients with amelanotic choroidal melanoma measuring less than 3 mm in thickness. The main outcome measures were tumor regression, final visual acuity, tumor recurrence, distant metastasis, and mortality.

Results: : The mean patient age was 57 years (range 42-71 years). There were 3 female (60%) and 2 male (40%) patients. The mean visual acuity at presentation was 20/20 (range 20/20-20/200). The quadrantic location of the tumor was nasal in 2 patients (40%), temporal in 2 patients (40%), and superior in 1 case (20%). Four patients had a non-pigmented choroidal melanoma (80%) and 1 had a partially pigmented tumor (20%). The mean tumor basal diameter at presentation was 8.8 mm (range 6-12 mm) and thickness 2.6 mm (range 2.3-2.9 mm). The mean number of PDT sessions was 1.6 (range 1-3). After mean follow-up of 12 months (range 5-20 months), the mean tumor thickness regression was -36% (range -59% to -3.7%). The mean visual acuity after treatment was 20/25 (range 20/20-20/400). None of the patients developed tumor recurrence at a mean follow- up of 12 months. All five patients were alive at the last follow-up without systemic metastasis.

Conclusions: : PDT might be effective for control of small amelanotic choroidal melanoma. Mean visual acuity was preserved at the last visit, with decrease of 1 line. There were no PDT-related complications. Long-term follow-up is required to evaluate local and systemic tumor outcomes.

Keywords: photodynamic therapy • melanoma • choroid 
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