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Sahitya V. Reddy, Kiran Turaka, Rishav D. Kansal, Zunair A. Mahmood, Carlos Bianciotto, Carol L. Shields; Photodynamic Therapy For The Treatment Of Amelanotic Choroidal Melanoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3278.
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To evaluate the efficacy and safety of photodynamic therapy (PDT) for treatment of amelanotic choroidal melanomas.
Retrospective review of medical records. The participants were five consecutive patients with amelanotic choroidal melanoma measuring less than 3 mm in thickness. The main outcome measures were tumor regression, final visual acuity, tumor recurrence, distant metastasis, and mortality.
The mean patient age was 57 years (range 42-71 years). There were 3 female (60%) and 2 male (40%) patients. The mean visual acuity at presentation was 20/20 (range 20/20-20/200). The quadrantic location of the tumor was nasal in 2 patients (40%), temporal in 2 patients (40%), and superior in 1 case (20%). Four patients had a non-pigmented choroidal melanoma (80%) and 1 had a partially pigmented tumor (20%). The mean tumor basal diameter at presentation was 8.8 mm (range 6-12 mm) and thickness 2.6 mm (range 2.3-2.9 mm). The mean number of PDT sessions was 1.6 (range 1-3). After mean follow-up of 12 months (range 5-20 months), the mean tumor thickness regression was -36% (range -59% to -3.7%). The mean visual acuity after treatment was 20/25 (range 20/20-20/400). None of the patients developed tumor recurrence at a mean follow- up of 12 months. All five patients were alive at the last follow-up without systemic metastasis.
PDT might be effective for control of small amelanotic choroidal melanoma. Mean visual acuity was preserved at the last visit, with decrease of 1 line. There were no PDT-related complications. Long-term follow-up is required to evaluate local and systemic tumor outcomes.
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