April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Serum Survivin Levels In Patients With Uveal Melanoma- A Promising Biomarker?
Author Affiliations & Notes
  • Inna G. Georgieva
    ophthalmology department, Charite-CBF, University hospital, Berlin, Germany
  • Michael H. Foerster
    DRK Klinik Berlin, Westend Berlin, Germany
  • Antonia M. Joussen
    ophthalmology department, Charite-CBF, University hospital, Berlin, Germany
  • Footnotes
    Commercial Relationships  Inna G. Georgieva, None; Michael H. Foerster, None; Antonia M. Joussen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3288. doi:
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      Inna G. Georgieva, Michael H. Foerster, Antonia M. Joussen; Serum Survivin Levels In Patients With Uveal Melanoma- A Promising Biomarker?. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3288.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Detection of survivin in the serum of patients with uveal melanoma (UM) and establishment of a method by which these levels can be used as treatment predictive value

Methods: : The serum samples were obtained from patients with UM (n=24) and healthy volunteers (n=23) after given informed consent. Most of the patients suffered from newly diagnosed uveal melanoma. The mean tumor prominence was 7,93mm (range 3.4-11.7mm). Five patients had metastatic disease and received chemotherapy. The mean age of patients with uveal melanoma was 67.46 years (range 36- 81).Survivin serum levels were determined using enzyme-linked immunoabsorbent assay (ELISA).

Results: : Increase of the survivin protein serum levels in patients with UM compared to the healthy controls, however without statistical significance (t-test p= 0.06). The serum levels tend to be higher in patients with a greater tumor burden or metastasis.

Conclusions: : The first study quantifying survivin protein levels in patients with uveal melanoma.

Keywords: melanoma 
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