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Paulina Haas, Tina Aggermann, Astrid Dossenbach, Susanne Binder; Complement Receptor 1 Density Polymorphism And Cfh As Risk Factors For Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3305.
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To determine a possible implication of complement receptor 1 density polymorphism in the pathogenesis of age-related macular degeneration. The aim is to asses the distribution of the complement receptor 1 density polymorphism and the CFH Y402H polymorphism and the presence of AMD in the Austrian population of Caucasoid descent.
98 patients were included in this case-controlled study. Genomic DNA was isolated from peripheral blood samples taken from 50 AMD patients and 48 age-matched healthy controls. The Complement receptor 1 density polymorphism and the Y402H polymorphism in CFH were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. The association between the genetic polymorphism and the disease were examined by chi(2) test and logistic regression.
Genotype frequency of the Complement receptor 1 density polymorphism and the Y402H polymorphism in CFH differed significantly between the two groups showing a p-value < 0.04.
Our data shows that more components of the complement system have a key role in the process of age-related macular degeneration.
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