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Nuo Dong, Cheng Li, Wei Li; Down-regulation Of Pax6 In Pterygial Epithelium. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3389.
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To evaluate the expression of Pax6 in pterygia epithelium.
Fifteen patients (15 eyes) with pterygium who underwent simple excision were enrolled in this study. Pax6, K10, K19 and MUC5AC immunostaining were performed in pterygia tissue and normal conjunctiva.
Abnormal epidermal differentiation of pterygia epithelium evidenced by decline or absence of Pax6 expression was accompanied by a decline or absence of K19 keratin and MUC5AC but increase of K10 keratin expression.
These results indicate that down-regulation of Pax6 is associated with abnormal differentiation of the epithelial cells in pterygium.
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