April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Down-regulation Of Pax6 In Pterygial Epithelium
Author Affiliations & Notes
  • Nuo Dong
    Affiliated Xiamen Eye Center, Xiamen University, Xiamen, China
  • Cheng Li
    Affiliated Xiamen Eye Center, Xiamen University, Xiamen, China
  • Wei Li
    Affiliated Xiamen Eye Center, Xiamen University, Xiamen, China
  • Footnotes
    Commercial Relationships  Nuo Dong, None; Cheng Li, None; Wei Li, None
  • Footnotes
    Support  Project supported by the National Natural Science Foundation of China (Grant No. 81000367).
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3389. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Nuo Dong, Cheng Li, Wei Li; Down-regulation Of Pax6 In Pterygial Epithelium. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3389.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate the expression of Pax6 in pterygia epithelium.

Methods: : Fifteen patients (15 eyes) with pterygium who underwent simple excision were enrolled in this study. Pax6, K10, K19 and MUC5AC immunostaining were performed in pterygia tissue and normal conjunctiva.

Results: : Abnormal epidermal differentiation of pterygia epithelium evidenced by decline or absence of Pax6 expression was accompanied by a decline or absence of K19 keratin and MUC5AC but increase of K10 keratin expression.

Conclusions: : These results indicate that down-regulation of Pax6 is associated with abnormal differentiation of the epithelial cells in pterygium.

Keywords: conjunctiva • pterygium 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×