April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Association Between Intrauterine Growth Restriction and Severe Retinopathy of Prematurity
Author Affiliations & Notes
  • Xiaoyun E. Nong
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York
  • Aaron Nagiel
    Ophthalmology,
    Weill Cornell Medical College, New York, New York
  • Nina J. Jonsson
    Ophthalmology,
    Weill Cornell Medical College, New York, New York
  • Yoshihiro Yonekawa
    Ophthalmology,
    Weill Cornell Medical College, New York, New York
  • Ryan K. Wong
    Ophthalmology and Visual Sciences, Yale University School of Medicine, New Haven, Connecticut
  • Laure Henchoz
    Ophthalmology,
    Weill Cornell Medical College, New York, New York
  • William W. Frayer
    Pediatrics,
    Weill Cornell Medical College, New York, New York
  • Thomas C. Lee
    Ophthalmology, Childrens Hospital Los Angeles, Los Angeles, California
  • Michael F. Chiang
    Ophthalmology, Oregon Health Sciences University, Portland, Oregon
  • Robison V. Chan
    Ophthalmology,
    Weill Cornell Medical College, New York, New York
  • Footnotes
    Commercial Relationships  Xiaoyun E. Nong, None; Aaron Nagiel, None; Nina J. Jonsson, None; Yoshihiro Yonekawa, None; Ryan K. Wong, None; Laure Henchoz, None; William W. Frayer, None; Thomas C. Lee, None; Michael F. Chiang, None; Robison V. Chan, None
  • Footnotes
    Support  NIH Grant EY19474 (MFC), The St. Giles Foundation (RVPC), Departmental Grant from Research to Prevent Blindness (RVPC, YY, AN), Grant from Dr. Werner Jackstaedt Foundation, Wuppertal, Germany (NJJ)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3452. doi:
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      Xiaoyun E. Nong, Aaron Nagiel, Nina J. Jonsson, Yoshihiro Yonekawa, Ryan K. Wong, Laure Henchoz, William W. Frayer, Thomas C. Lee, Michael F. Chiang, Robison V. Chan; The Association Between Intrauterine Growth Restriction and Severe Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3452.

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Abstract

Purpose: : Retinopathy of prematurity (ROP) is a leading cause of blindness in children. Although low birth weight is a major risk factor for developing ROP, little is known about the association between low birth weight secondary to intrauterine growth restriction (IUGR) and ROP. The aim of the current study was to investigate the association between intrauterine growth restriction and severe retinopathy of prematurity requiring treatment.

Methods: : We performed a retrospective review of consecutive non-black inborn patients screened for ROP (GA < 32 weeks and/or BW < 1500 g) in the neonatal intensive care unit of the New York-Presbyterian Hospital-Weill Cornell Medical Center from June 2002 to August 2008. IUGR was defined as a birth weight less than the tenth percentile for that gestational age. We used birth weight percentile cutoffs from an updated version of Babson and Benda's fetal growth chart. Patients were divided into IUGR and non-IUGR groups.

Results: : Our study included 373 infants, of whom 43 (11.5%) were born IUGR and 330 (88.5%) were not IUGR with mean BW’s of 939g and 1264g, respectively (P<0.05). GA, oxygen exposure, and treatment criteria were comparable between both groups. Using single variable analyses, we did not observe strong data to suggest that risk of ROP for IUGR patients was different than in non-IUGR patients. The odds ratio (OR) and 95% confidence intervals (CI) were calculated to be: for the development of stage 0 [OR 0.86; 95% CI 0.40-2.30; P=0.73], stage 1 (OR 1.24; 95% CI 0.60-2.40; P=0.58), stage 2 (OR 0.80; 95% CI 0.30-2.20; P=0.66), stage 3 (OR 1.08; 95% CI 0.40-2.90; P=0.88), and treatment requiring ROP (OR 0.90; 95% CI 0.20-3.90; P=0.88).

Conclusions: : In this series, there was no difference in the development of treatment requiring ROP for patients identified as being born with IUGR and for those non-IUGR patients.

Keywords: retinopathy of prematurity • retina 
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