April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Effect of β-Zone Parapapillary Atrophy (βPPA) on Retinal Blood Flow Velocity in Primary Open-Angle Glaucoma (POAG) and Exfoliative Glaucoma (XFG)
Author Affiliations & Notes
  • Nicole Scripsema
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • Syril Dorairaj
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • Ruojin Ren
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • Sung Chul Park
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Dept. of Ophthalmology, New York Medical College, Valhalla, New York
  • Gennady Landa
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • Katy Tai
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • Paul A. Sidoti
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Dept. of Ophthalmology, New York Medical College, Valhalla, New York
  • Richard B. Rosen
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Dept. of Ophthalmology, New York Medical College, Valhalla, New York
  • Robert Ritch
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Dept. of Ophthalmology, New York Medical College, Valhalla, New York
  • Footnotes
    Commercial Relationships  Nicole Scripsema, None; Syril Dorairaj, None; Ruojin Ren, None; Sung Chul Park, None; Gennady Landa, None; Katy Tai, None; Paul A. Sidoti, None; Richard B. Rosen, OD-OS Clarity (F), OPKO-OTI (F), Topcon Medical System, Inc (F); Robert Ritch, Carl Zeiss Meditec, Ing (F), Heidelberg Engineering GmBH (F), Topcon Medical System, Inc (F)
  • Footnotes
    Support  Bendheim-Lowenstein Retina Fund of the New York Eye and Ear Infirmary; Ira and Judith Robinson Research Fund of the New York Glaucoma Research Institute, New York, NY
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3477. doi:
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      Nicole Scripsema, Syril Dorairaj, Ruojin Ren, Sung Chul Park, Gennady Landa, Katy Tai, Paul A. Sidoti, Richard B. Rosen, Robert Ritch; Effect of β-Zone Parapapillary Atrophy (βPPA) on Retinal Blood Flow Velocity in Primary Open-Angle Glaucoma (POAG) and Exfoliative Glaucoma (XFG). Invest. Ophthalmol. Vis. Sci. 2011;52(14):3477.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Ocular blood flow (BF) is known to be reduced in glaucoma, but the relationship between reduced BF and βPPA is unclear. Using the Retinal Functional Imager (RFI), we evaluated the effect of βPPA on the peripapillary retinal BF velocities of secondary and tertiary vessels in POAG and XFG.

 
Methods:
 

Patients with POAG and XFG with no previous ocular surgery (with the exception of cataract extraction and laser iridotomy) were included in this prospective study. Peripapillary retinal arterial and venous BF velocities were evaluated with RFI. Color fundus photographs were reviewed by two glaucoma specialists and patients were divided into four subgroups based on the presence or absence of βPPA. The four subgroups consisted of eyes with POAG without βPPA, POAG with βPPA, XFG without βPPA, and XFG with βPPA.

 
Results:
 

A total of 73 POAG and 46 XFG eyes were included. The demographic and clinical parameters for each group, including retinal BF velocities, are summarized in Table 1. Mean age was significantly greater in the XFG without βPPA group than the other 3 groups (p>0.3). Before and after controlling for age, all 3 BF velocity parameters (mean arterial and venous BF velocities and mean velocity difference between artery and vein) were not significantly different between the POAG groups with and without βPPA (p>0.6) or between the XFG groups with and without βPPA (p>0.3). BF velocity parameters were also similar between the POAG and XFG groups with (p>0.9) or without βPPA (p>0.4).

 
Conclusions:
 

Presence of βPPA is not significantly correlated to changes in peripapillary retinal BF velocities in POAG or XFG. Retinal perfusion may be similar between POAG and XFG of similar stage.  

 
Keywords: imaging/image analysis: clinical • blood supply • optic nerve 
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