April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Assessment of Retinal Blood Flow in Glaucoma by Fourier-domain Doppler OCT and Correlation with Other Diagnostic Modalities
Author Affiliations & Notes
  • John C. Hwang
    Doheny Retina Institute, Los Angeles, California
  • Ranjith Konduru
    Doheny Retina Institute, Los Angeles, California
  • Ou Tan
    Ophthalmology, Univ Southern CA & Doheny Eye Inst, Los Angeles, California
  • Brian A. Francis
    Ophthalmology, Doheny Eye Institute, Los Angeles, California
  • Rohit Varma
    Ophthalmology, USC, Doheny Eye Institute, Los Angeles, California
  • Srinivas R. Sadda
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
  • Footnotes
    Commercial Relationships  John C. Hwang, None; Ranjith Konduru, None; Ou Tan, grant support from Optovue, Inc (R); Brian A. Francis, None; Rohit Varma, None; Srinivas R. Sadda, coinventor of intellectual property and receives royalties related to spectral domain optical coherence tomography that has been licensed from the Doheny Eye Institute by Topcon Medical Systems (P), consulting fees from Heidelberg Engineering and Genentech (C); David Huang, optical coherence tomography patent licensed to Carl Zeiss Meditec, Inc. (Dublin, CA, USA) (P), stock options, travel support, research grants, and patent royalties from Optovue, Inc (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3482. doi:
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      John C. Hwang, Ranjith Konduru, Ou Tan, Brian A. Francis, Rohit Varma, Srinivas R. Sadda, David Huang; Assessment of Retinal Blood Flow in Glaucoma by Fourier-domain Doppler OCT and Correlation with Other Diagnostic Modalities. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3482.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate: (1) the difference in total retinal blood flow between glaucomatous eyes and normal eyes using Doppler spectral-domain optical coherence tomography (Doppler OCT) and (2) the correlation between retinal blood flow and other measures of glaucoma severity.

Methods: : Eight eyes of seven glaucoma subjects and nine eyes of nine control subjects were evaluated by multiple modalities including Doppler OCT (Optovue RTVue SD-OCT), OCT for retinal nerve fiber layer thickness (Zeiss Stratus OCT), confocal laser ophthalmoscopy (Heidelberg Retinal Tomography), scanning laser polarimetry (Zeiss GDx), and conventional static perimetry (Zeiss Humphrey 750i Visual Field Analyzer). Doppler OCT was performed using previously described dual circular scanning protocols. The semi-automated Doppler OCT Reading Center (DOCTORC) software was used by certified reading center graders to verify and refine vessel positions and calculate blood flow velocities from all arteries and veins near the optic nerve head. Retinal blood flow measurements were correlated with measurements from other diagnostic modalities used to diagnose and monitor patients with glaucoma.

Results: : Total retinal blood flow was significantly decreased in glaucoma eyes (36.9 microliters/min) compared to control eyes (49.5 microliters/min) (p=0.001). Arterial cross-sectional area was significantly reduced and venous velocity demonstrated a trend toward reduction (p=0.06). Arterial velocity and venous cross-sectional area remained stable. The decrease in retinal blood flow was significantly correlated with the severity of glaucoma as measured by static perimetry (mean deviation and pattern standard deviation), OCT retinal nerve fiber layer analysis, confocal laser ophthalmoscopy, and scanning laser polarimetry (p=0.01).

Conclusions: : Retinal blood flow as measured by Doppler OCT is significantly reduced in eyes with glaucoma and the degree of reduction is correlated with disease severity. Retinal blood flow may be a useful metric in the diagnosis and management of glaucoma and further studies are warranted.

Keywords: blood supply • imaging/image analysis: clinical • optic nerve 

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