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Anna Schwarz, Eugen Gramer, Constantin Reiter, Nicole Weisschuh, Gwendolyn Gramer; Frequent Blood Donations and Blood Loss - Risk Factors for Visual Field Loss in Patients with Normal Tension Glaucoma?. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3483.
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Whether frequent blood donations (BD) are a risk factor for visual field loss (VFL) has not been evaluated yet. Literature suggests that blood loss is a risk factor in normal tension glaucoma (NTG). I. To evaluate prospectively the relative frequency of glaucoma patients donating blood and the number of BD in patients with NTG. Does the incidence of BD or severe blood loss requiring blood transfusions significantly differ from control groups of patients with PEX glaucoma (PEX G) or pigmentary glaucoma (PG)? II. Do NTG patients with frequent BD show significantly more frequently advanced stages of visual field loss (VFL) than NTG patients without BD?
I. By means of a standardized questionnaire, 168 NTG patients were asked whether they had donated blood, how many BD had been performed, and whether they had experienced severe blood loss requiring blood transfusions due to injury or surgery. The control groups consisted of 153 patients with PEX G and 92 patients with PG. II. Two NTG sub-groups were compared: 123 patients without any BD and 24 patients with frequent (10-90) BD. VFL was staged according to Aulhorn classification. For statistical analysis, the eye with the more severe stage of VFL was used. Statistics: Fisher’s exact test, chi-square test.
I. Blood donation was found in more than every fourth glaucoma patient: NTG 28.0%, PEX G 27.5%, PG 28.3%. In patients with PEX G, blood loss requiring blood transfusions was significantly more common than in patients with NTG (p= 0.0185, chi-square test). II. NTG patients without BD showed no significant differences in the stage of VFL compared to NTG patients with frequent BD (p= 0.66, Fisher’s exact test).
1. Even numerous BD showed no association with more severe stages of VFL in NTG patients. 2. There is a surprisingly high incidence of BD in glaucoma patients without significant differences between NTG, PEX G and PG. 3. Patients with PEX G reported significantly more frequently blood loss requiring blood transfusions. We suggest that this might be due to their higher age and to the systemic PEX involvement.
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