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Matthew D. Lazzara; Sub-foveal Choroidal Thickness Analysis with Optical Coherence Tomography in Asymmetric Pseudoexfoliation Glacuoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3490.
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To measure and compare relative macular choroidal thickness (CT) in patients with asymmetric glaucoma secondary to pseudoexfoliation using optical coherence tomography (OCT).
OCT images were obtained in thirteen patients with pseudoexfoliation (PXF) syndrome with asymmetric disease. Both those with ocular hypertension and overt glaucoma were included and analyzed as a single and separate cohort. Patients were excluded if they were found to have significant concomitant retinal or choroidal pathologic processes. A single line-averaged macular scan horizontally through the fovea was obtained along with nerve fiber layer (NFL) OCT data for both eyes of each patient. The choroid was measured from the outer border of the retinal pigment epithelium to the inner scleral border at 500-um intervals: extending 2.5 mm nasally and 2.5 mm temporally centered on the fovea. CT measurements averaged over the 5mm scan, at the nasal border, and at the fovea were analyzed.
The choroidal thickness was found to be significantly thinner in the subfoveal region of the more affected eye in 9 of 11 patients measured. The average subfoveal choroidal thickness in the affected eyes was 176.4 microns, versus 226.2 microns in the unaffected eyes (p=0.01).
Whether secondary to chronic intra-ocular pressure differences or inherent changes in the choroidal vasculature, the subfoveal choroidal thickness was found to be thinner in the eye more affected by glaucoma in asymmetric cases associated with pseudoexfoliation syndrome.
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