Correlation Between Ocular Perfusion Pressure Fluctuation And Glaucoma Severity

Abstract

Purpose: : To assess the correlation between ocular perfusion pressure (OPP) fluctuation and the severity of glaucoma

Methods: : Thirty-two patients with primary open-angle glaucoma (POAG) enrolled the study. All subjects had intraocular pressure and blood pressure measured at three time points (7 a.m., 1 p.m., and 7 p.m.). OPP fluctuation was calculated as the range between the highest and the lowest value. OPP fluctuation was correlated with a structural measure (cup-to-disk ratio) and two functional measures (MD and PSD values from automated perimetry) with the Pearson’s correlation coefficient

Results: : OPP fluctuation showed weak but statistically significant correlation with MD (r² = 0.29, P = 0.04) and PDS (r² = 0.35, P = 0.01). No correlation was found between OPP fluctuation and cup-to-disk ratio (r² = 0.09, P = 0.2)

Conclusions: : POAG patients with higher OPP fluctuation have greater severity of disease as measured by functional parameters

Keywords: blood supply • optic disc • perimetry