April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Photopic Erg B-wave Amplitude In Neuromyelitis Optica
Author Affiliations & Notes
  • Katharina Stecher
    Ophthalmology,
    University of Sao Paulo, Ribeirao Preto, Brazil
  • Doralina G. Brum
    Neurology,
    University of Sao Paulo, Ribeirao Preto, Brazil
  • Amilton A. Barreira
    Neurology,
    University of Sao Paulo, Ribeirao Preto, Brazil
  • Jayter S. de Paula
    Ophthalmology,
    University of Sao Paulo, Ribeirao Preto, Brazil
  • Andre Messias
    Ophthalmology,
    University of Sao Paulo, Ribeirao Preto, Brazil
  • Footnotes
    Commercial Relationships  Katharina Stecher, None; Doralina G. Brum, None; Amilton A. Barreira, None; Jayter S. de Paula, None; Andre Messias, None
  • Footnotes
    Support  FAPESP Grant: 2007/59078-8
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3512. doi:
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      Katharina Stecher, Doralina G. Brum, Amilton A. Barreira, Jayter S. de Paula, Andre Messias; Photopic Erg B-wave Amplitude In Neuromyelitis Optica. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3512.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To describe light-adapted electroretinogram (ERGs) b-wave responses in a series of patients with neuromyelitis optica (NMO).

Methods: : After comprehensive ophthalmological evaluation including best-corrected visual acuity measurement(BCVA), ERGs were recorded in 11 patients (7 anti-aquaporin-4 antibody-positive). 5 patients experienced bilateral and 6 unilateral optical neuritis, consequently 16 eyes NMO optical neuritis (group NO) and 6 unaffected fellow-eyes (FE). As control group (CTRL), eyes from 21 normally-sighted subjects, in the same age range, were examined. ERG protocol was based on ISCEV standard, extended with a light-adapted luminance-response series to derive descriptors for the interrelation between b-wave amplitude and stimuli energy, from an non-normalized Gaussian function: h: saturation amplitude; x0: luminance for saturation, and w: non-dimensional slope-related parameter. Optical coherence tomography (OCT) was performed for retinal nerve fiber layer thickness (RNFL) measurement.

Results: : BCVA ranged from no-light-perception to 20/25 in NO and was 20/20 or better in CTRL and FE. Mean±SD light-adapted b-wave saturation amplitude (µV), parameter h, was NO: 172.36 ± 49.32; and FE: 148.15 ± 65.88, showing no statistically significant difference to CTRL: 182.80 ± 26.71 (P=0.4190; ANOVA), while parameter x0 (cd.s/m2) was increased in NO: 0.91 ± 0.31 and in FE: 0.80 ± 0.24 in comparison to CTRL: 0.54 ± 0.07 (P<0.05). Overall RNFL ranged from 33 to 79 µm in NO but was within the normative range for FE and CTRL.

Conclusions: : We found abnormalities for the interrelation between light-adapted b-wave amplitude and stimuli luminance in NO and FE with normal BCVA and RNFL. Light-adapted ERG might add valuable information for diagnosis and follow-up in NMO.

Keywords: electroretinography: clinical • retina • visual impairment: neuro-ophthalmological disease 
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