April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Peripheral Autofluorescence Changes in Patients with Geographic Atrophy secondary to Dry ARMD
Author Affiliations & Notes
  • Ute E. Wolf-Schnurrbusch
    Universitaetsklinik fur Augenheilkunde, University Bern, Bern, Switzerland
  • Jean-Francois Korobelnik
    Service d'Ophtalmologie, Hopital Pellegrin, Bordeaux, France
  • Martin Niederhaeuser
    Universitaetsklinik fur Augenheilkunde, University Bern, Bern, Switzerland
  • Sebastian Wolf
    Universitatsklinik fur Augenheilkunde, University of Bern, Bern, Switzerland
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3531. doi:
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      Ute E. Wolf-Schnurrbusch, Jean-Francois Korobelnik, Martin Niederhaeuser, Sebastian Wolf; Peripheral Autofluorescence Changes in Patients with Geographic Atrophy secondary to Dry ARMD. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3531.

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Abstract
 
Purpose:
 

The aim of our study was to evaluate peripheral changes in patients with geographic atrophy (GA) due to dry ARMD (group 1) in comparison with age-matched normal controls (group 2).

 
Methods:
 

After clinical examination undilated wide-angle digital autofluorescence images (AF) and color images were taken with the Optos P200CAF ultra-wide angle laser scanning ophthalmoscope (cSLO) to determine the phenotype variation in the macula and in the periphery. Images were graded in random order without access to clinical information. The distribution and prevalence of AF changes and atrophic patches was recorded in three zones: the macular zone, mid-periphery and the far periphery.

 
Results:
 

In total 52 patients (mean age 75±7 years, range 63-91 years) with GA (group 1) and 52 age-matched controls (group 2, mean age 76±3 years, range 63-92 years) were included into the study. In patients with GA we found atrophicfound atrophic patches in the macular zone and the mid-periphery in all patients. In addition we observed atrophic patches in 47 % also in the far periphery in this group. In the age-matched normal controls we found atrophic patches in the macular zone in 23%, the mid-periphery in 31% and the far periphery in only 18%.

 
Conclusions:
 

The Optos P200CAF has value in retinal imaging for assessment of GA and could improve our knowledge regarding peripheral changes in well known diseases like dry ARMD. The far periphery is much more altered in patients with central pathologic changes like GA secondary to ARMD than in age-matched controls.

 
Clinical Trial:
 

http://www.clinicaltrials.gov NCT00494325

 
Keywords: age-related macular degeneration • retinal pigment epithelium • imaging/image analysis: clinical 
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