April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Anti-VEGF Therapy for Peripapillary Choroidal Neovascularization
Author Affiliations & Notes
  • Andrew S. Davis
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • James C. Folk
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Stephen R. Russell
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • H. Culver Boldt
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Edwin M. Stone
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Michael D. Abramoff
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Vinit B. Mahajan
    Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Footnotes
    Commercial Relationships  Andrew S. Davis, None; James C. Folk, None; Stephen R. Russell, None; H. Culver Boldt, None; Edwin M. Stone, None; Michael D. Abramoff, None; Vinit B. Mahajan, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3544. doi:
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    • Get Citation

      Andrew S. Davis, James C. Folk, Stephen R. Russell, H. Culver Boldt, Edwin M. Stone, Michael D. Abramoff, Vinit B. Mahajan; Anti-VEGF Therapy for Peripapillary Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3544.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the response of peripapillary choroidal neovascularization (CNV) to intravitreal injection of antibodies to vascular endothelial growth factor (anti-VEGF).

 
Methods:
 

Retrospective case series. A chart review was conducted to identify patients with peripapillary CNV that did not involve the fovea and received only anti-VEGF treatment. The demographic data, visual acuities, complications, number of injections and remission periods were reviewed. Recurrent subretinal or intraretinal fluid on spectral domain OCT was the indication for reinjection.

 
Results:
 

21 eyes from 20 patients were found to have peripapillary CNV, including 14 eyes with AMD, 4 eyes with presumed ocular histoplasmosis, 1 eye with choroidal rupture, and 2 eyes with unknown etiology. 2/21 eyes were treated with a combination of bevacizumab and ranibizumab and 19/21 eyes received only bevacizumab. Patients received an average of 5.95 injections (range 2-18) for each involved eye. An average of 2.9 (range 1-9) intravitreal injections were required to control the lesions. 18/21 eyes had lesions that went into remission. 14/18 eyes remained in remission for an average of 8.4 months (range 1-31). 4/18 eyes had recurrent fluid following an average 6.25 month treatment interval (range 3-8). The pre-injection visual acuity averaged 20/40 (range of 20/20-20/100). The post-injection visually acuity averaged 20/30 (range 20/15-20/60). The mean follow up was 16.75 months (range 3-58 months). There were no adverse events related to treatment.

 
Conclusions:
 

Anti-VEGF therapy is effective for peripapillary CNV with good visual outcomes, but requires careful monitoring for recurrence.

 
Keywords: choroid: neovascularization • choroid • vascular endothelial growth factor 
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