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Yasser M. Tariq, Haitao Li, George Burlutsky, Paul Mitchell, Sydney Adolescent Vascular Eye Study; Macular, Retinal Nerve Fiber Layer and Optic Disc Parameters Measured by Spectral Domain OCT in Normal Adolescent Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3596.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the normative distribution of macular, retinal nerve fiber layer and optic disc parameters in normal eyes of adolescent children as measured by spectral domain optical coherence tomography (OCT).
As part of the Sydney Adolescent Vascular and Eye Study, school children in Sydney were tested during 2009 and 2010. Retinal measurements were performed by OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). The exam protocol included assessment of visual acuity, cycloplegic autorefraction and ocular biometry measurement.
1054 children had complete data; their mean age was 17.3 years (range 15 to 18), and 49.3% were male. The mean (±SD) central macular thickness was 256.0±19.9µm, and the average thickness of the macular 6mm square was 284.3±12.6µm. The average retinal nerve fiber layer thickness (RNFL) was found to be 99.5±9.6µm. The RNFL thickness for the temporal, superior nasal and inferior quadrants was 69.9±11.2, 124.7±15.7, 74.3±12.8 and 128.8±17.1µm, respectively. The mean optic disc rim area was 1.50±0.30mm2, the mean disc area was 1.97±0.37mm2, and the mean cup-disc-ratio was 0.41±0.17. In analysis adjusted for age, axial length and ethnicity, average and central macular thickness was significantly thicker in boys compared to girls (mean difference 6.0 and 11.0µm, respectively, both P<0.0001). Boys were found to have larger cup-disc-ratios compared with girls (mean difference 0.04, P = 0.0003). However, no significant gender difference was found for average RNFL.
This study documents normative values for spectral domain OCT parameters in 17 year old adolescents.
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