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Liang Xu, Ya Xing Wang, Shuang Wang, Jost B. Jonas; Mortality And Retinal Vascular Abnormalities In Adult Chinese, The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3598.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between mortality and retinal vascular abnormalities.
At baseline in 2001, the Beijing Eye Study examined 4439 subjects with an age of 40+ years. The mean age was 56.2 ± 10.6 years (40 - 101 years). In 2006, all study participants were re-invited for a follow-up examination. We examined focal and generalized arteriolar narrowing, arteriolar sheathing, and arteriovenous crossing abnormalities.
Out of the 4439 subjects examined in the 2001, 3251 (73.2%) subjects returned for the follow-up examination, while 143 (3.2%) subjects were dead and 1045 (23.5%) subjects were alive however did not agree to be re-examined. Fundus photographs were available for 8655 eyes of 4376 (98.6%) subjects. In binary logistic regression analysis, mortality was significantly associated with retinal focal arteriolar narrowing (P=0.050), generalized arteriolar narrowing (P<0.001), and arteriovenous nicking (P=0.004), but not with areteriorlar sheathing (P=0.109). When the effect of age was considered, mortality was significantly associated with generalized arteriolar narrowing (P=0.009), and arteriovenous nicking (P=0.031) using multi-variant regression
Retinal vascular abnormalities were associated with an increased mortality in the adult Chinese population. Retinal vessels evaluation might be helpful for indicating systematic health status.
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