April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Mortality And Retinal Vascular Abnormalities In Adult Chinese, The Beijing Eye Study
Author Affiliations & Notes
  • Liang Xu
    Beijing Institue of Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Ya Xing Wang
    Beijing Tongren Hospital,
    Beijing Institute of Ophthalmology, Beijing, China
  • Shuang Wang
    Ophthalmology,
    Beijing Institute of Ophthalmology, Beijing, China
  • Jost B. Jonas
    Ophthalmology, Fac Clin Med Mannheim-Heidelberg, Mannheim, Germany
  • Footnotes
    Commercial Relationships  Liang Xu, None; Ya Xing Wang, None; Shuang Wang, None; Jost B. Jonas, None
  • Footnotes
    Support  Beijing Key Laboratory Fund and the Beijing Natural Science Foundation
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3598. doi:
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      Liang Xu, Ya Xing Wang, Shuang Wang, Jost B. Jonas; Mortality And Retinal Vascular Abnormalities In Adult Chinese, The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3598.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the relationship between mortality and retinal vascular abnormalities.

Methods: : At baseline in 2001, the Beijing Eye Study examined 4439 subjects with an age of 40+ years. The mean age was 56.2 ± 10.6 years (40 - 101 years). In 2006, all study participants were re-invited for a follow-up examination. We examined focal and generalized arteriolar narrowing, arteriolar sheathing, and arteriovenous crossing abnormalities.

Results: : Out of the 4439 subjects examined in the 2001, 3251 (73.2%) subjects returned for the follow-up examination, while 143 (3.2%) subjects were dead and 1045 (23.5%) subjects were alive however did not agree to be re-examined. Fundus photographs were available for 8655 eyes of 4376 (98.6%) subjects. In binary logistic regression analysis, mortality was significantly associated with retinal focal arteriolar narrowing (P=0.050), generalized arteriolar narrowing (P<0.001), and arteriovenous nicking (P=0.004), but not with areteriorlar sheathing (P=0.109). When the effect of age was considered, mortality was significantly associated with generalized arteriolar narrowing (P=0.009), and arteriovenous nicking (P=0.031) using multi-variant regression

Conclusions: : Retinal vascular abnormalities were associated with an increased mortality in the adult Chinese population. Retinal vessels evaluation might be helpful for indicating systematic health status.

Keywords: clinical (human) or epidemiologic studies: natural history • blood supply 
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