April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Asteroid Hyalosis in Malay and Indian Asian populations
Author Affiliations & Notes
  • Gavin S. Tan
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore
  • Wan-Ling Wong
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore
  • Tien Y. Wong
    Singapore National Eye Centre and Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Gavin S. Tan, None; Wan-Ling Wong, None; Tien Y. Wong, None
  • Footnotes
    Support  Grants from the National Medical Research Council (STaR/0003/2008) & (0796/2003), the Singapore Bio Imaging Consortium (C-011/2006) and the Biomedical Research Council (501/1/25-5 ) & (08/1/35/19/550)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 3599. doi:
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      Gavin S. Tan, Wan-Ling Wong, Tien Y. Wong; Asteroid Hyalosis in Malay and Indian Asian populations. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3599.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To estimate the prevalence and examine the associations of Asteroid Hyalosis (AH) in 2 Asian populations.

Methods: : The Singapore Malay Eye Study (SIMES) is a population-based cross-sectional survey that included 3280 ethnic Malays aged 40-80 years. The Singapore Indian Eye Study (SINDI) is a population-based cross-sectional sample of 3400 ethnic Indians aged 40-80+ years. The study population was selected using an age-stratified random sampling procedure of Malay and Indian adults respectively, living in the south-western part of Singapore. Examination procedures included interviews, measurement of blood pressure, anthropometry, presenting and best-corrected visual acuity, subjective refraction, ocular biometry, Goldmann applanation tonometry, slit-lamp biomicroscopy, optic disc imaging and digital photography of the lens and retina, using a standardized protocol. Blood and urine samples were collected for biochemical analyses. Presence of AH was graded based on digital photography of the retina.

Results: : There were 3275 subjects from SIMES and 3337 subjects from SINDI with retina photographs graded for asteroid hyalosis. The prevalence of AH was 0.49% (95%CI 0.25%, 0.73%) in SIMES and 0.75%(95%CI 0.46%, 1.04%) in SINDI (p=0.180). Overall prevalence was 0.62% (95%CI 0.45%, 0.84%). AH was bilateral in 3 subjects in SINDI only. In the entire cohort, prevalence of AH increased significantly with age from 0.24% in the 40-49 age group to 1.57% in the 70+ age group. (p<0.001). On multivariate analysis of the combined cohort, AH was significantly associated with age (OR 1.48, p=0.027), race (Indian OR 2.610, p=0.022) and shorter axial length. (OR 0.606, p=0.016). On examining each racial group separately, in Malays, AH was significantly associated with age (OR 3.47, p=0.005), history of angina (OR 7.63, p=0.027) and history of thyroid disease (OR 10.0, p=0.007). In Indians, AH was associated with higher serum high density lipoprotein cholesterol (OR 9.13, p=0.043) and shorted axial length (OR 0.54, p=0.014). There was no statistically significant association found with gender, diabetes, serum cholesterol, serum triglycerides, alcohol consumption, smoking, history of stroke, intraocular pressure, refractive error or body mass index.

Conclusions: : Asteroid hyalosis was detected infrequently in Malay and Indian populations. There was a significant association with race and axial length.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • vitreous • clinical (human) or epidemiologic studies: risk factor assessment 
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