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Gavin S. Tan, Wan-Ling Wong, Tien Y. Wong; Asteroid Hyalosis in Malay and Indian Asian populations. Invest. Ophthalmol. Vis. Sci. 2011;52(14):3599.
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To estimate the prevalence and examine the associations of Asteroid Hyalosis (AH) in 2 Asian populations.
The Singapore Malay Eye Study (SIMES) is a population-based cross-sectional survey that included 3280 ethnic Malays aged 40-80 years. The Singapore Indian Eye Study (SINDI) is a population-based cross-sectional sample of 3400 ethnic Indians aged 40-80+ years. The study population was selected using an age-stratified random sampling procedure of Malay and Indian adults respectively, living in the south-western part of Singapore. Examination procedures included interviews, measurement of blood pressure, anthropometry, presenting and best-corrected visual acuity, subjective refraction, ocular biometry, Goldmann applanation tonometry, slit-lamp biomicroscopy, optic disc imaging and digital photography of the lens and retina, using a standardized protocol. Blood and urine samples were collected for biochemical analyses. Presence of AH was graded based on digital photography of the retina.
There were 3275 subjects from SIMES and 3337 subjects from SINDI with retina photographs graded for asteroid hyalosis. The prevalence of AH was 0.49% (95%CI 0.25%, 0.73%) in SIMES and 0.75%(95%CI 0.46%, 1.04%) in SINDI (p=0.180). Overall prevalence was 0.62% (95%CI 0.45%, 0.84%). AH was bilateral in 3 subjects in SINDI only. In the entire cohort, prevalence of AH increased significantly with age from 0.24% in the 40-49 age group to 1.57% in the 70+ age group. (p<0.001). On multivariate analysis of the combined cohort, AH was significantly associated with age (OR 1.48, p=0.027), race (Indian OR 2.610, p=0.022) and shorter axial length. (OR 0.606, p=0.016). On examining each racial group separately, in Malays, AH was significantly associated with age (OR 3.47, p=0.005), history of angina (OR 7.63, p=0.027) and history of thyroid disease (OR 10.0, p=0.007). In Indians, AH was associated with higher serum high density lipoprotein cholesterol (OR 9.13, p=0.043) and shorted axial length (OR 0.54, p=0.014). There was no statistically significant association found with gender, diabetes, serum cholesterol, serum triglycerides, alcohol consumption, smoking, history of stroke, intraocular pressure, refractive error or body mass index.
Asteroid hyalosis was detected infrequently in Malay and Indian populations. There was a significant association with race and axial length.
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